YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Regulatory Role of Chenodeoxycholic Acid on the Proliferation of Osteoclast Precursor Cells

Chenodeoxycholic Acid에 의한 파골전구세포의 증식 조절

  • Received : 2014.02.13
  • Accepted : 2014.04.28
  • Published : 2014.06.30
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Abstract

We investigated the effect of Chenodeoxycholic acid (CDCA) on the proliferation of osteoclast precursor cells. CDCA decreased the proliferation of osteoclast precursor cells through the control of cell cycle regulators such as cyclin D1, p21 and p27. When we checked the signaling pathway, CDCA decreased Erk activation in osteoclast precursor cells. Furthermore, two bile acid receptors, FXR and TGR5, were involved in the suppressive effect of CDCA. Taken together, this study suggested that bile acid plays an important role in the proliferation of osteoclast precursor cells.

Keywords

References

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