The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effects of Portulacae Herba (PH) on Allergic Contact Dermatitis (ACD) Induced by DNCB in Mice

마치현(馬齒莧)이 DNCB로 유발된 생쥐의 알레르기성 접촉피부염에 미치는 영향

  • Lee, Jong-Cheol (Dept. of Oriental Medicine Graduate School of Dongshin University) ;
  • Park, Soo-Yeon (Dept. of Oriental Medicine Graduate School of Dongshin University) ;
  • Choi, Jung-Hwa (Dept. of Oriental Medicine Graduate School of Dongshin University) ;
  • Kim, Jong-Han (Dept. of Oriental Medicine Graduate School of Dongshin University)
  • 이종철 (동신대학교 한의과대학 한방안이비인후과학교실) ;
  • 박수연 (동신대학교 한의과대학 한방안이비인후과학교실) ;
  • 최정화 (동신대학교 한의과대학 한방안이비인후과학교실) ;
  • 김종한 (동신대학교 한의과대학 한방안이비인후과학교실)
  • Received : 2014.07.15
  • Accepted : 2014.08.15
  • Published : 2014.08.25
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Abstract

Objective : Portulacae Herba (PH) can clear away heat, detoxicate, cool down blood heat. The present study was designed to investigate the effects of PH on ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Method : In this experiment, the effects of PH on changes in body weights, thicknesses and weights of ear, thicknesses of dorsum skin, degree of symptoms on the dorsum skin, histopathological changes of ear and dorsum skin, spleen weights, TNF-${\alpha}$ and IL-10 in serum were observed. And the effects on the proliferation rates of splenocytes were also investigated in vitro and in vivo. Results : 1. PH spread (PHS) group and PH spread plus administered (PHS+Adm) group didn't show any changes in weight and thickness of ear. 2. But in PHS and PHS+Adm group, thickness of dorsum skin decreased significantly. 3. And PHS and PHS+Adm group showed meaningful effectiveness on ACD symptoms like erythema, desquamation and keratinization. 4. In histopathological observation, hyperplasia and edema of spongy tissues were remarkably diminished in PHS and PHS+Adm group. 5. And PH reduced the proliferation rates of splenocytes in vivo and vitro study. Conclusions : PH effectively decreased symptoms of ACD in this study, therefore PH can be one of medicinal ingredients to treat ACD.

Keywords

References

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