Asian Pacific Journal of Cancer Prevention

  • 제15권9호
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  • Pages.4079-4083
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Increased Argonaute 2 Expression in Gliomas and its Association with Tumor Progression and Poor Prognosis

  • Feng, Bo (Department of Neurology, Hospital Affiliated to Binzhou medical University) ;
  • Hu, Peng (Department of Spine, Hospital Affiliated to Binzhou medical University) ;
  • Lu, Shu-Jun (Department of Neurology, Hospital Affiliated to Binzhou medical University) ;
  • Chen, Jin-Bo (Department of Neurology, Hospital Affiliated to Binzhou medical University) ;
  • Ge, Ru-Li (Department of Neurology, Hospital Affiliated to Binzhou medical University)
  • 발행 : 2014.05.15
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초록

Background: Previous studies have showed that argonaute 2 is a potential factor related to genesis of several cancers, however, there have been no reports concerning gliomas. Methods: Paraffin specimens of 129 brain glioma cases were collected from a hospital affiliated to Binzhou Medical University from January 2008 to July 2013. We examined both argonaute 2 mRNA and protein expression by real-time quantitative PCR (qRT-PCR), Western blot analysis, and immunohistochemistry (IHC). The survival curves of the patients were determined using the Kaplan-Meier method and Cox regression, and the log-rank test was used for statistical evaluations. Results: Both argonaute 2 mRNA and protein were upregulated in high-grade when compared to low-grade tumor tissues. Multivariate analysis revealed that argonaute 2 protein expression was independently associated with the overall survival (HR=4.587, 95% CI: 3.001-6.993; P=0.002), and that argonaute 2 protein expression and WHO grading were independent prognostic factors for progression-free survival (HR=4.792, 95% CI: 3.993-5.672; P<0.001, and HR=2.109, 95% CI: 1.278-8.229; P=0.039, respectively). Kaplan-Meier analysis with the log-rank test indicated that high argonaute 2 protein expression had a significant impact on overall survival (P=0.0169) and progression-free survival (P=0.0324). Conclusions: The present study showed that argonaute 2 expression is up-regulated in gliomas. Argonaute 2 might also serve as a novel prognostic marker.

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피인용 문헌

  1. High Expression of Forkhead Box Protein C2 is Related to Poor Prognosis in Human Gliomas vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10621
  2. Expression of p16 and Survivin in gliomas and their correlation with cell proliferation pp.1792-1082, 2015, https://doi.org/10.3892/ol.2015.3180