Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
권호 표지
DOI QR코드

DOI QR Code

In Vitro Mammalian Chromosomal Aberration Test of Allyl Chloride for Workers' Health

근로자의 건강보호를 위한 알릴 염화물의 포유류 배양세포 염색체이상시험

  • Rim, Kyung-Taek (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kim, Soo-Jin (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • 임경택 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김수진 (한국산업안전보건공단 산업안전보건연구원)
  • Received : 2014.02.17
  • Accepted : 2014.06.11
  • Published : 2014.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Chemical hazard evaluations are important for workers' health and working environments. Allyl chloride (CAS No. 107-05-1) is used in many industries, leading to concerns about the possibility of threats to the health of workers. Since only insufficient or controversial information is available about potential related hazards, an in vitro mammalian chromosomal aberration (CA) assay was conducted in order to gain additional information concerning any such hazards. Moreover, toxicological information from this study could be applied for workers' rights to know, and to prepare or update the Materials Safety Data Sheet (MSDS) for a number of industries. Methods and Results: The assay was performed using the Chinese hamster lung fibroblast cell (ATCC, CRL-1935), by the direct method (-S9) and by the metabolic activated method (+S9 mix). Using the direct method, the seven dosages in the 48-hour treatment group did not show that the frequency of CA is proportionate to the dosage. The frequency of CA is not proportionate to the dosage addition for a six-hour treatment using the metabolic activated method. Conclusions: From these findings, it was decided that this chemical does not induce chromosomal aberrations under the tested conditions.

Keywords

References

  1. American Conference of Governmental Industrial Hygienists(ACGIH). Documentation of threshold limit values for chemical substances and physical agents and biological exposure indices. Ohio: 2001, p. 4
  2. American Conference of Governmental Industrial Hygienists(ACGIH). TLVs and BEIs. Threshold limit values for chemical substances and physical agents and biological exposure indices. Ohio: 2008, p. 11
  3. Bingham E, Cohrssen B, Powell CH. Patty's Toxicology Volumes 1-9 5th ed. New York: John Wiley & Sons. Inc.; 2001. p. 225
  4. Environmental Protection Agency(EPA). U.S. Environmental Protection Agency's Integrated Risk Information System(IRIS). Summary on allyl chloride(107-05-1) [serial online] 2000 March [cited 2014 Feb]; Available from: URL:http://www.epa.gov/iris/
  5. Environmental Protection Agency(EPA). Office of Pollution Prevention and Toxics; High Production Volume(HPV) challenge program. 1-Propene, 3-chloro-(107-05-1). [serial online] 2005 Dec [cited 2014 Feb]; Available from: URL:http://www.epa.gov/hpv/pubs/general/opptsrch.htm
  6. Hawley GG. The condensed chemical dictionary. 9th ed. New York: Van Nostrand Reinhold Co.; 1977. p. 29
  7. International Agency for Research on Cancer(IARC). Monographs on the evaluation of the carcinogenic risk of chemicals to man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT.(Multivolume work). [serial online] 1999 [cited 2014 Feb]; Available from: URL:http://monographs.iarc.fr/index.php p. V71 1236 (1999)
  8. International Labour Office(ILO). Encyclopedia of occupational health and safety. Vols. I&II. Geneva, Switzerland: 1983. p. 128
  9. International Programme on Chemical Safety(IPCS), CEC; International chemical safety card on allyl chloride. [serial online] 2005 July [cited 2014 Feb]; Available from: URL:http://www.inchem.org/documents/icsc/icsc/eics0010.htm
  10. Ishidate M Jr, Sofuni T. The in vitro chromosomal aberration test using Chinese hamster lung(CHL) fibroblast cells in culture. In: Ashby J, editor. Progress in mutation research. 1985;5:427-32
  11. Lewis RJ. Sax's Dangerous properties of industrial materials, 9th ed. Volumes 1-3. New York: Van Nostrand Reinhold Co.; 1996. p. 96
  12. National Institute of Environmental Research(NIER). GLP notice No. 2013-1 for hazard assessment with chemicals in environment. Incheon, Korea: Ministry of Environment; 2013
  13. National Institutes of Health(NIH). Bioassay of allyl chloride for possible carcinogenicity(Date) technical report series No. 73 DHEW Pub No. 78-1323. Maryland: U.S. Department of Health Education and Welfare, National Cancer Institute; 1978
  14. National Fire Protection Association(NFPA). Fire protection guide to hazardous materials. 13 ed. Quincy, MA:, 2002. p. 49-15
  15. National Institute for Occupational Safety and Health (NIOSH). International safety cards. Allyl chloride. 107-05-1. [serial online] 2005 July [cited 2014 Feb]; Available from: URL:http//www.cdc.gov/niosh/ipcs/nicstart.html
  16. National Institute for Occupational Safety and Health(NIOSH). NIOSH Pocket guide to chemical hazards & other databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. DHHS(NIOSH) Publication No. 2004-103.; 2003.
  17. O'Neil MJ. The Merck index - An encyclopedia of chemicals, drugs, and biologicals. 13th Edition, Whitehouse Station, Merck and Co. Inc., New Jersey: 2001. p. 54
  18. Organization for Economic Co-operation and Development (OECD). Test No. 473: In vitro mammalian chromosome aberration test. OECD Guidelines for the testing of chemicals. Paris, France: 1997;1:1-10.