Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Relationship between flavonoids intake and metabolic syndrome in Korean women with polycystic ovary syndrome

한국 다낭난소증후군 환자에서 대사증후군과 식이 플라보노이드 섭취와의 관련성

  • Oh, Ji Soo (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Ahn, Mi Jin (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Han, Chan Jung (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Kim, Hyesook (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Kwon, Oran (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Chung, Hye Won (Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine) ;
  • Chang, Namsoo (Department of Nutritional Science and Food Management, Ewha Womans University)
  • 오지수 (이화여자대학교 식품영양학과) ;
  • 안미진 (이화여자대학교 식품영양학과) ;
  • 한찬정 (이화여자대학교 식품영양학과) ;
  • 김혜숙 (이화여자대학교 식품영양학과) ;
  • 권오란 (이화여자대학교 식품영양학과) ;
  • 정혜원 (이화여자대학교 의학전문대학원 산부인과교실) ;
  • 장남수 (이화여자대학교 식품영양학과)
  • Received : 2014.03.17
  • Accepted : 2014.06.03
  • Published : 2014.06.30
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Abstract

Purpose: The purpose of this study was to investigate the relationship between dietary flavonoids intake and metabolic syndrome (MetS) in Korean women with polycystic ovary syndrome (PCOS). Methods: A total of 223 subjects (mean age; $27.3{\pm}4.2$ yrs, range; 17-38 yrs) were divided into the MetS group (n = 27) and non-MetS group (n = 196). Dietary intake data were assessed by 24-hour recall method for two non-consecutive days and the average of the two days was used to estimate the usual dietary intake. Dietary habits were assessed using the Mini Dietary Assessment (MDA) score. We analyzed the intakes of six flavonoid classes (anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, and iso-flavones) using a flavonoids database. Results: After adjustment for age, total energy intake, alcohol consumption, smoking, regular exercise, and oral contraceptive use, dietary flavonols intake was significantly lower in the MetS group ($5.1{\pm}2.4$ mg/d) than in the non-MetS group ($8.9{\pm}2.8$ mg/d) (p = 0.0472). Intakes of other flavonoids except for flavonols did not differ between the two groups. In MDA scores, significant differences were observed only for that related to daily consumption of fruit or fruit juice (p = 0.0180). A significant inverse relationship was observed between flavonols intake and the risk of MetS (4th vs. 1st quartile, OR = 0.11, 95% CI = 0.02-0.62, p for trend = 0.0131). Conclusion: These results suggest that higher intake of flavonols may be beneficial for MetS in PCOS women.

본 연구는 PCOS 환자를 대상으로 MetS 여부에 따른 플라보노이드 섭취량의 차이를 분석하고 MetS과 플라보노이드 섭취와의 관련성을 알아보기 위해 수행되었다. 이 연구를 통해 관찰된 결과는 다음과 같다. 첫째, MetS이 없는 군에 비해 MetS이 있는 군은 총 6종의 플라보노이드군 중 플라보놀 (flavonols)을 유의적으로 적게 섭취하는 것으로 나타났다. 둘째, 간이식생활진단 (MDA)을 통한 식습관을 조사한 결과, '과일이나 과일주스를 매일 먹는다'라는 질문에 대해 '아닌 편이다'라고 응답한 비율이 MetS이 없는 군에 비해 MetS이 있는 군이 높았다. 셋째, 플라보놀 (flavonols)의 섭취량과 MetS의 교차비 (OR)를 분석한 결과, 모든 혼란변수를 보정한 후, 최하위 섭취군 대비 최상위 섭취군에서 MetS에 대한 교차비가 유의적으로 낮았다. 이상 PCOS 환자를 대상으로 MetS과 플라보노이드 섭취와의 관련성을 조사한 결과, MetS이 있는 군이 MetS이 없는 군에 비해 플라보놀 (flavonols)의 섭취량이 유의적으로 낮았고 플라보놀 (flavonols)의 섭취량은 MetS의 위험도와 역의 관계를 나타냈다.

Keywords

References

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