마황(麻黃) Hexane 분획물이 생쥐의 지질 대사에 미치는 영향

Effects of Ephedra Herba Hexane Fraction on Lipid Metabolism in Hyperlipidemic Mice

  • 김경민 (동의대학교 한의과대학 순환신경내과학교실) ;
  • 김영균 (동의대학교 한의과대학 순환신경내과학교실) ;
  • 신길조 (동국대학교 한의과대학 한방내과)
  • Kim, Kyoung Min (Depa. of Caridovascular & Neurologic Disease, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Young Kyun (Depa. of Caridovascular & Neurologic Disease, College of Oriental Medicine, Dong-Eui University) ;
  • Shin, Gil cho (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Guk University)
  • 발행 : 2014.08.01

초록

■ Objectives This study was designed to investigate the effects of Ephedra Herba hexane fraction on lipid levels in serum and lipid accumulation in liver tissue in Hyperlipidemic mice. ■ Methods Hyperlipidemia was induced by providing high fat diet for 4 weeks. Normal group was provided with normal diet. CTL groupwas provided with high fat diet. Ephedra Herba hexane fraction group was provieded with high fat diet and administered orally in the concentration of 1.5mg/kg body weight/day for 2 weeks. In this experiment, effects on total cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. In addition histopathological changes in liver tissue were also observed. ■ Results Ephedra Herba hexane fraction did not affects weight gain, serum AST and ALT in hyperlipidemic mice. Oral administration of Ephedra Herba hexane fraction lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. In addition, Ephedra Herba hexane fraction group showed downward tendency of lipid accumulation compared with CTL group. Finally, administration of Ephedra Herba hexane fraction lowered fasting blood glucose significantly. And Ephedra Herba hexane fraction also ameliorates anti-oxidative stress systems in internal organs which play key role in disease prevention. ■ Conclusion These results suggest that Ephedra Herba hexane fraction can prevent lipid accumulation in liver tissue through regulation of dyslipidemia and hyperglycaemia.

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