Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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SFannotation: A Simple and Fast Protein Function Annotation System

  • Yu, Dong Su (Korean BioInformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kim, Byung Kwon (BioNano Health Guard Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
  • Received : 2014.05.09
  • Accepted : 2014.05.23
  • Published : 2014.06.30
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Abstract

Owing to the generation of vast amounts of sequencing data by using cost-effective, high-throughput sequencing technologies with improved computational approaches, many putative proteins have been discovered after assembly and structural annotation. Putative proteins are typically annotated using a functional annotation system that uses extant databases, but the expansive size of these databases often causes a bottleneck for rapid functional annotation. We developed SFannotation, a simple and fast functional annotation system that rapidly annotates putative proteins against four extant databases, Swiss-Prot, TIGRFAMs, Pfam, and the non-redundant sequence database, by using a best-hit approach with BLASTP and HMMSEARCH.

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References

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