Journal of Acupuncture Research

  • 제31권2호
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  • Pages.39-50
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  • 2014
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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음곡에 시술한 비해약침이 Lipopolysaccharide로 유도된 흰쥐의 신장염에 미치는 영향

The Effect of Tokoro Rhizoma Pharmacopuncture at $KI_{10}$ in Lipopolysaccharide Induced Acute Nephritis in Rats

  • 김윤주 (대전대학교 한의과대학 침구의학교실) ;
  • 강재희 (대전대학교 한의과대학 침구의학교실) ;
  • 이현 (대전대학교 한의과대학 침구의학교실)
  • Kim, Yun Joo (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kang, Jae Hui (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daejeon University) ;
  • Lee, Hyun (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daejeon University)
  • 투고 : 2014.05.10
  • 심사 : 2014.06.09
  • 발행 : 2014.06.20
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초록

Objectives : This study was designed to evaluate the effects of Tokoro Rhizoma pharmat $KI_{10}$ in nephritis induced by lipopolysaccharide(LPS) in rat. Methods : Rats were divided into 4 groups and 3 groups(LPS, saline, Tokoro Rhizoma pharmacopuncture(TR-P) group) were injected LPS to induce nephritis. TR-P group was treated with TR at $KI_{10}$ three times for a week, saline group with normal saline. To evaluate the effects of TR at $KI_{10}$ on nephritis in rats, white blood cell(WBC), neutrophil in blood, creatinine, cytokine-induced neutrophil chemoattractant-1(CINC-1) in serum and urinary volume, creatinine in urine, renal myeloperoxidase(MPO) were measured and renal tissue was analyzed. Results : TR-P group significantly reduced WBC, neutrophil in blood, creatinine, CINC-1 in serum, creatinine in urine and renal MPO than LPS group. TR-P group increased urinary volume but, not significant. Conclusion : TR at $KI_{10}$ has a therapeutic effect on nephritis in LPS stimulated rat. Therefore, it is suggested that TR at $KI_{10}$ may be an useful therapeutics for nephritis in clinical field after further researches.

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