Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Nanotechnology Biomimetic Cartilage Regenerative Scaffolds

  • Lim, Erh-Hsuin (The Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London) ;
  • Sardinha, Jose Paulo (Department of Materials and Institute of Biomedical Engineering, Imperial College London) ;
  • Myers, Simon (The Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London)
  • Received : 2013.06.06
  • Accepted : 2013.06.30
  • Published : 2014.05.15
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Abstract

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery.

Keywords

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