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Deracemization of Racemic Amino Acids Using (R)- and (S)-Alanine Racemase Chiral Analogues as Chiral Converters

  • Received : 2014.03.10
  • Accepted : 2014.03.19
  • Published : 2014.07.20

Abstract

Keywords

Experimental

The chemicals used in this study were purchased from Aldrich (Milwaukee, WI) or Fluka (Switzerland) and were analytical-reagent grade. (R)- and (S)-ARCA were provided by Aminologics Company (Sungnam, Korea). The amino acid stereoconversion samples using (R)- and (S)-ARCA were prepared as described previously.2-5 HPLC studies were carried out using a Breeze system (Waters, Milford, MA) equipped with a binary pump (Waters model 1525), an autosampler, and a dual absorbance detector (Waters 2487 detector). Capcell Pak C18 UG 120 (250 × 4.6 mm I.D., 5 μm) (Shiseido Company, Japan) for diastereomer analysis and ChiroSil SCA (250 × 4.6 mm I.D., 5 μm) (RS Tech, Daejon, Korea) based on (−)-18-C-6-TA for enantiomer analysis were used.10,11

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