YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum

호장으로부터 분리한 스틸벤류의 Nitric Oxide 저해활성

  • Joo, Si Mong (College of Pharmacy, Sookmyung Women's University) ;
  • Hong, Yun Jung (College of Pharmacy, Sookmyung Women's University) ;
  • Yang, Ki Sook (College of Pharmacy, Sookmyung Women's University)
  • 주시몽 (숙명여자대학교 약학대학) ;
  • 홍윤정 (숙명여자대학교 약학대학) ;
  • 양기숙 (숙명여자대학교 약학대학)
  • Received : 2013.11.12
  • Accepted : 2014.02.17
  • Published : 2014.02.28
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Abstract

Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea, favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and antiinflammatory activity by measuring DPPH radical scavenging activity and the inhibition of IFN-${\gamma}$ and LPS-induced NO production in RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-${\beta}$-Dglucopyranoside (2). Compounds 1 and 2 showed potent activities compared with L-NMMA ($N^G$-monomethyl-L-arginine). These results suggested that the stilbene compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.

Keywords

References

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