YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Development of Alternative Assay Method without Hazardous Reagent, Chloroform for Urazamide Tablets in Korean Pharmaceutical Codex

우라자미드 정의 유해시약 대체 시험법의 개발

  • Lee, Yoo Rim (College of Pharmacy, Kangwon National University) ;
  • Kim, Hyun Ji (College of Pharmacy, Kangwon National University) ;
  • Seo, Narae (College of Pharmacy, Kangwon National University) ;
  • Kim, Kyeong Ho (College of Pharmacy, Kangwon National University)
  • Received : 2014.03.04
  • Accepted : 2014.03.28
  • Published : 2014.04.30
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Abstract

We developed an alternative assay method without hazardous reagent of chloroform for urazamide tablets in Korean Pharmaceutical Codex. The HPLC analytical method was validated by system suitability, linearity, precision, accuracy and robustness. The linearity of the calibration curves in the desired concentration range is good ($r^2$ >0.999). Precision was obtained less than RSD 1.17%. Accuracy was obtained with recoveries in range of 98.12% and 99.47%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

Keywords

References

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