Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Glutathione S-Transferase T1 and M1 Polymorphisms and Risk of Uterine Cervical Lesions in Women from Central Serbia

  • Published : 2014.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to investigate the frequencies of GSTT1 and GSTM1 deletion polymorphisms in newly-diagnosed patients with uterine cervical lesions from central Serbia. Polymorphisms of GST genes were genotyped in 97 patients with cervical lesions and 50 healthy women using a multiplex polymerase chain reaction (PCR). The GSTM1 null genotype was significantly more prominent among the patients than in controls (74.2% vs 56.0%), the risk associated with lesions being almost 2.3-fold increased (OR=2.26, 95%CI=1.10-4.65, p=0.03) and 3.17-fold higher in patients above >45 years old (95%CI=1.02-9.79, p=0.04). The analysis of the two genotypes demonstrated that GSTM1 null genotype significantly increased risk only for low grade squamous intraepithelial lesion-LSIL (OR=2.81, 95%CI=1.03-7.68, p=0.04). GSTT1 null genotype or different genotype combinations were not found to be risk factors, irrespective to lesion stages, age or smoking. We found that the risk of cervical lesions might be significantly related to the GSTM1 null genotype, especially in women aged above 45 years. Furthermore, the GSTM1 polymorphism might have greater role in development of early stage lesions.

Keywords

References

  1. Abdel-Rahman SZ, El-Zein RA, Anwar WA, Au WW (1996). A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies. Cancer Lett, 107, 229-33. https://doi.org/10.1016/0304-3835(96)04832-X
  2. Agorastos T, Papadopoulos N, Lambropoulos AF, et al (2007). Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women. Eur J Cancer Prev, 16, 498-504. https://doi.org/10.1097/01.cej.0000243859.99265.92
  3. Ansari BS, Vasudevan R, Mirinargesi M, et al (2009). Lack of association of glutathione s-transferase gene polymorphisms in Iranian prostate cancer subjects. Am J Biochem Biotechnol, 5, 30-4. https://doi.org/10.3844/ajbbsp.2009.30.34
  4. Ates NA, Tamer L, Ates C, et al (2005). Glutathione S-transferase M1, T1, P1 genotypes and risk for development of colorectal cancer. Biochem Genet, 43, 149-63. https://doi.org/10.1007/s10528-005-1508-z
  5. Cseh J, Pazsit E, Orsos Z, et al (2011). Effect of glutathione-S-transferase M1 and T1 allelic polymorphisms on HPV-induced cervical precancer formation. Anticancer Res, 31, 3051-5.
  6. de Carvalho CR, da Silva ID, Pereira JS, et al (2008). Polymorphisms of p53, GSTM1 and GSTT1, and HPV in uterine cervix adenocarcinoma. Eur J Gynaecol Oncol, 29, 590-3.
  7. Economopoulos KP, Choussein S, Vlahos NF, Sergentanis TN (2010). GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: a meta-analysis. Int J Gynecol Cancer, 20, 1576-80.
  8. Evans MF, Adamson CS, Papillo JL, et al (2006). Distribution of human papillomavirus types in thinprep papanicolaou tests classified according to the bethesda 2001 terminology and correlations with patient age and biopsy outcomes. Cancer, 106, 1054-64. https://doi.org/10.1002/cncr.21664
  9. Gao LB, Pan XM, Li LJ, et al (2011). Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: an evidence-based meta-analysis. PLoS One, 6, 20157. https://doi.org/10.1371/journal.pone.0020157
  10. Goodman MT, McDuffie K, Hernandez B, et al (2001). CYP1A1, GSTM1, and GSTT1 polymorphisms and the risk of cervical squamous intraepithelial lesions in a multiethnic population. Gynecol Oncol, 81, 263-9. https://doi.org/10.1006/gyno.2001.6154
  11. Jancova P, Anzenbacher P, Anzenbacherov E (2010). Phase II drug metabolizing enzymes. Biomed Pap, 154, 103-16. https://doi.org/10.5507/bp.2010.017
  12. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  13. Kiran B, Karkucak M, Ozan H, et al (2010). GST (GSTM1, GSTT1, and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer. J Gynecol Oncol, 21, 169-73. https://doi.org/10.3802/jgo.2010.21.3.169
  14. Kondo S, Sturgis EM, Li F, Wei Q, Li G (2009). GSTM1 and GSTT1 null polymorphisms and risk of salivary gland carcinoma. Int J Clin Exp Med, 2, 68-75.
  15. McCann MF, Irwin DE, Walton LA, et al (1992). Nicotine and cotinine in the cervical mucus of smokers, passive smokers, and nonsmokers. Cancer Epidemiol Biomarkers Prev, 1, 125-9.
  16. Palma S, Novelli F, Padua L, et al (2010). Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk. J Cancer Res Clin Oncol, 136, 1101-9. https://doi.org/10.1007/s00432-009-0757-3
  17. Peng J, Liu HZ, Zhu YJ (2014). Null glutathione S-transferase T1 and M1 genotypes and oral cancer susceptibility in China and India-a Meta-analysis. Asian Pac J Cancer Prev, 15, 287-90. https://doi.org/10.7314/APJCP.2014.15.1.287
  18. Piao JM, Shin MH, Kim HN, et al (2013). Glutathione-S-transferase (GSTM1, GSTT1) null phenotypes and risk of lung cancer in a Korean population. Asian Pac J Cancer Prev, 14, 7165-9. https://doi.org/10.7314/APJCP.2013.14.12.7165
  19. Prokopczyk B, Cox JE, Hoffmann D, Waggoner SE (1997). Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers. J Natl Cancer Inst, 89, 868-73. https://doi.org/10.1093/jnci/89.12.868
  20. Settheetham-Ishida W, Yuenyao P, Kularbkaew C, Settheetham D, Ishida T (2009). Glutathione S-transferase (GSTM1 and GSTT1) polymorphisms in cervical cancer in northeastern Thailand. Asian Pac J Cancer Prev, 10, 365-8.
  21. Sharma A, Sharma JK, Murthy NS, Mitra AB (2004). Polymorphisms at GSTM1 and GSTT1 gene loci and susceptibility to cervical cancer in Indian population. Neoplasma, 51, 12-6.
  22. Sierra-Torres CH, Au WW, Arrastia CD, et al (2003). Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia. Environ Mol Mutagen, 41, 69-76. https://doi.org/10.1002/em.10132
  23. Singh H, Sachan R, Devi S, Pandey SN, Mittal B (2008). Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a north Indian population. Am J Obstet Gynecol, 198, 3031-6. https://doi.org/10.1016/j.ajog.2007.09.046
  24. Singh M, Shah PP, Singh AP, et al (2008). Association of genetic polymorphisms in glutathione S-transferases and susceptibility to head and neck cancer. Mutat Res, 638, 184-94. https://doi.org/10.1016/j.mrfmmm.2007.10.003
  25. Sivonova M, Waczulikova I, Dobrota D, et al (2009). Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study. J Exp Clin Cancer Res, 28, 32. https://doi.org/10.1186/1756-9966-28-32
  26. Sobti RC, Kaur S, Kaur P, et al (2006). Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India. Cancer Genet Cytogenet, 166, 117-23. https://doi.org/10.1016/j.cancergencyto.2005.10.001
  27. Sui Y, Han W, Yang Z, Jiang M, Li J (2011). Association of glutathione S-transferase M1 and T1 null polymorphisms with the development of cervical lesions: a meta-analysis. Eur J Obstet Gynecol Reprod Biol, 159, 443-8. https://doi.org/10.1016/j.ejogrb.2011.09.012
  28. Taspinar M, Aydos SE, Comez O, et al (2008). CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia. Swiss Med Wkly, 138, 12-7.
  29. Ueda M, Toji E, Nunobiki O, et al (2010). Germline polymorphisms of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 in cervical carcinogenesis. Hum Cell, 23, 119-25. https://doi.org/10.1111/j.1749-0774.2010.00089.x
  30. Wang D, Wang B, Zhai JX, Liu DW, Sun GG (2011). Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: a meta-analysis. Neoplasma, 58, 352-9. https://doi.org/10.4149/neo_2011_04_352
  31. Warwick A, Sarhanis P, Redman C, et al (1994a). Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking. Carcinogenesis, 15, 2841-5. https://doi.org/10.1093/carcin/15.12.2841
  32. Warwick AP, Redman CW, Jones PW, et al (1994b). Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione S-transferase GSTM1 null genotypes and cigarette smoking. Br J Cancer, 70, 704-8. https://doi.org/10.1038/bjc.1994.378
  33. Zhang ZY, Jin XY, Wu R, et al (2012). Meta-analysis of the association between GSTM1 and GSTT1 gene polymorphisms and cervical cancer. Asian Pac J Cancer Prev, 13, 815-9. https://doi.org/10.7314/APJCP.2012.13.3.815
  34. Zuna RE, Allen RA, Moore WE, et al (2007). Distribution of HPV genotypes in 282 women with cervical lesions: evidence for three categories of intraepithelial lesions based on morphology and HPV type. Mod Pathol, 20, 167-74. https://doi.org/10.1038/modpathol.3800723

Cited by

  1. Glutathione S-transferase M1 and T1 Polymorphisms, Cigarette Smoking and HPV Infection in Precancerous and Cancerous Lesions of the Uterine Cervix vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6429
  2. Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.1935
  3. GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review vol.40, pp.4, 2017, https://doi.org/10.1590/1678-4685-gmb-2016-0142