Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Positive Effects of Oral β-Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX-4 Combination Chemotherapy

  • Karaca, Halit (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Bozkurt, Oktay (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Ozaslan, Ersin (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Baldane, Suleyman (Department of Internal Medicine, Erciyes University Medical Faculty) ;
  • Berk, Veli (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Inanc, Mevlude (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Duran, Ayse Ocak (Department of Medical Oncology, Erciyes University Medical Faculty) ;
  • Dikilitas, Mustafa (Department of Medical Oncology, Acibadem Hospital) ;
  • Er, Ozlem (Department of Medical Oncology, Acibadem Hospital) ;
  • Ozkan, Metin (Department of Medical Oncology, Erciyes University Medical Faculty)
  • Published : 2014.04.30
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Abstract

The present study aimed to determine the effect of oral ${\beta}$-glucan on mucositis and leukopenia in 62 consecutive patients with colorectal cancer treated with an adjuvant FOLFOX-4 regimen. The patients were retrospectively evaluated in 2 groups: one group received ${\beta}$-glucan and the other did not (control group). Leucocytes, neutrophils, and platelets were evaluated before and 1 week after chemotherapy and oral mucositis and diarrhea were noted. Leucocyte and neutrophil counts after chemotherapy in the ${\beta}$-glucan group were $7,300/mm^3$ and $3,800/mm^3$, respectively, and the reductions, as compared to baseline, were not significant (p=0.673 and 0.784). The median platelet count was $264,000/mm^3$ after chemotherapy in the ${\beta}$-glucan group and the reduction, as compared to baseline, was borderline significant (p=0.048). In the control group, reduction in leucocyte, neutrophil, and platelet counts was statistically significant. Oral mucositis and diarrhea were less common in the ${\beta}$-glucan group. We conclude that ${\beta}$-glucan can be used to reduce the adverse effects of chemotherapy.

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References

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