DOI QR코드

DOI QR Code

Levels of Serum 25-Hydroxy-Vitamin D in Benign and Malignant Breast Masses

  • Alipour, Sadaf (Department of Surgery, Arash Women's Hospital) ;
  • Hadji, Maryam (Cancer Research Center, Dr. Shariati Hospital, Tehran University of Medical Sciences) ;
  • Hosseini, Ladan (Research Development Center, Arash Women's Hospital) ;
  • Omranipour, Ramesh (Department of Surgery, Cancer Institute, Dr. Shariati Hospital, Tehran University of Medical Sciences) ;
  • Saberi, Azin (Department of Surgery, Arash Women's Hospital) ;
  • Seifollahi, Akram (Department of Pathology, Arash Women's Hospital) ;
  • Bayani, Leila (Department of Radiology, Arash Women's Hospital) ;
  • Shirzad, Nooshin (Endocrinology and Metabolism Research Institute, Dr. Shariati Hospital, Tehran University of Medical Sciences)
  • 발행 : 2014.01.15

초록

Background: The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses and controls. Materials and Methods: Levels of vitamin D were measured by electrochemiluminescense. Serum levels >35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severe vitamin D deficiency, respectively. Results: Overall, 364 women were included in the control, 172 in the benign and 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancers than controls. Levels were also lower in malignant than benign cases and in benign cases than controls although statistically non-significant. Conclusions: Multinomial logistic regression analysis showed that severe vitamin D deficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate and mild deficiency.

키워드

참고문헌

  1. Bener A, El Ayoubi HR (2012). The role of vitamin D deficiency and osteoporosis in breast cancer. Int J Rheum Dis, 15, 554-61. https://doi.org/10.1111/1756-185x.12017
  2. Bilinski K, Boyages J (2013). Association between 25-hydroxyvitamin D concentration and breast cancer risk in an Australian population: an observational case-control study. Breast Cancer Res Treat, 137, 599-607. https://doi.org/10.1007/s10549-012-2381-1
  3. Chlebowski RT, Johnson KC, Kooperberg C, et al (2008). Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst, 100, 1581-91. https://doi.org/10.1093/jnci/djn360
  4. Chlebowski RT (2011). Vitamin D and breast cancer: interpreting current evidence. Breast Cancer Res, 13, 217. https://doi.org/10.1186/bcr2846
  5. Chlebowski RT (2013). Vitamin D and breast cancer incidence and outcome. Anticancer Agents Med Chem, 13, 98-106. https://doi.org/10.2174/187152013804487362
  6. Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA (2011). Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med, 155, 827-38. https://doi.org/10.7326/0003-4819-155-12-201112200-00005
  7. Eliassen AH, Spiegelman D, Hollis BW, et al (2011). Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II. Breast Cancer Res, 13, 50. https://doi.org/10.1186/bcr2880
  8. Engel P, Fagherazzi G, Boutten A, Dupre T, Mesrine S, Boutron-Ruault MC, Clavel-Chapelon F (2010). Serum 25(OH) vitamin D and risk of breast cancer: a nested case-control study from the French E3N cohort. Cancer Epidemiol Biomarkers Prev, 19, 2341-50. https://doi.org/10.1158/1055-9965.EPI-10-0264
  9. Engel P, Fagherazzi G, Mesrine S, Boutron-Ruault MC, Clavel-Chapelon F (2011). Joint effects of dietary vitamin D and sun exposure on breast cancer risk: results from the French E3N cohort. Cancer Epidemiol Biomarkers Prev, 20, 187-98. https://doi.org/10.1158/1055-9965.EPI-10-1039
  10. Fedirko V, Torres-Mejia G, Ortega-Olvera C, et al (2012). Serum 25-hydroxyvitamin D and risk of breast cancer: results of a large population-based case-control study in Mexican women. Cancer Causes Control, 23, 1149-62. https://doi.org/10.1007/s10552-012-9984-z
  11. Freedman DM, Chang SC, Falk RT, et al (2008). Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev, 17, 889-94. https://doi.org/10.1158/1055-9965.EPI-07-2594
  12. Grant WB (2010). Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers. J Photochem Photobiol B, 101, 130-6. https://doi.org/10.1016/j.jphotobiol.2010.04.008
  13. Gupta D, Vashi PG, Trukova K, Lis CG, Lammersfeld CA (2011). Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature. Exp Ther Med, 2, 181-93.
  14. Harirchi I, Kolahdoozan S, Karbakhsh M, et al (2011). Twenty years of breast cancer in Iran: downstaging without a formal screening program. Ann Oncol, 22, 93-7. https://doi.org/10.1093/annonc/mdq303
  15. Jacobs ET, Thomson CA, Flatt SW, et al (2011). Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study. Am J Clin Nutr, 93, 108-17. https://doi.org/10.3945/ajcn.2010.30009
  16. Kermani IA, Kojidi HT, Gharamaleki JV, et al (2011). Association of serum level of 25 hydroxy-vitamin D with prognostic factors for breast cancer. Asian Pac J Cancer Prev, 12, 1381-4.
  17. Lee MS, Huang YC, Wahlqvist ML, et al (2011). Vitamin D decreases risk of breast cancer in premenopausal women of normal weight in subtropical taiwan. J Epidemiol, 21, 87-94. https://doi.org/10.2188/jea.JE20100088
  18. Lippolis JD, Reinhardt TA, Sacco RA, Nonnecke BJ, Nelson CD (2011). Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D(3). PLoS One, 6, 25479. https://doi.org/10.1371/journal.pone.0025479
  19. Lopes N, Paredes J, Costa JL, Ylstra B, Schmitt F. (2012). Vitamin D and the mammary gland: a review on its role in normal development and breast cancer. Breast Cancer Res, 14, 211. https://doi.org/10.1186/bcr3178
  20. Mohr SB, Gorham ED, Alcaraz JE, et al (2011). Serum 25-hydroxyvitamin D and prevention of breast cancer: pooled analysis. Anticancer Res, 31, 2939-48.
  21. Mousavi SM, Montazeri A, Mohagheghi MA, et al (2007). Breast cancer in Iran: an epidemiological review. Breast J, 13, 383-91. https://doi.org/10.1111/j.1524-4741.2007.00446.x
  22. Ordonez-Mena JM, Schottker B, Haug U, et al (2013). Serum 25-Hydroxyvitamin D and Cancer Risk in Older Adults: Results from a Large German Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev, 22, 905-16 https://doi.org/10.1158/1055-9965.EPI-12-1332
  23. Pazdiora P, Svobodova S, Fuchsova R, et al (2011). Vitamin D in colorectal, breast, prostate and lung cancer: a pilot study. Anticancer Res, 31, 3619-21.
  24. Peppone LJ, Rickles AS, Janelsins MC, Insalaco MR, Skinner KA (2012). The association between breast cancer prognostic indicators and serum 25-OH vitamin D levels. Ann Surg Oncol, 19, 2590-9. https://doi.org/10.1245/s10434-012-2297-3
  25. Rohan TE, Negassa A, Chlebowski RT, et al (2009). A randomized controlled trial of calcium plus vitamin D supplementation and risk of benign proliferative breast disease. Breast Cancer Res Treat, 116, 339-50. https://doi.org/10.1007/s10549-008-0213-0
  26. Shamsi U, Khan S, Usman S, Soomro S, Azam I (2013). A multicenter matched case control study of breast cancer risk factors among women in Karachi, Pakistan. Asian Pac J Cancer Prev, 14, 183-8. https://doi.org/10.7314/APJCP.2013.14.1.183
  27. Shao T, Klein P, Grossbard ML (2012). Vitamin D and breast cancer. Oncologist, 17, 36-45. https://doi.org/10.1634/theoncologist.2011-0278
  28. Su X, Colditz GA, Collins LC, et al (2012). Adolescent intakes of vitamin D and calcium and incidence of proliferative benign breast disease. Breast Cancer Res Treat, 134, 783-91. https://doi.org/10.1007/s10549-012-2091-8
  29. Vobecky J, Simard A, Vobecky JS, et al (1993). Nutritional profile of women with fibrocystic breast disease. Int J Epidemiol, 22, 989-99. https://doi.org/10.1093/ije/22.6.989
  30. Yao S, Sucheston LE, Millen AE, Johnson CS, et al (2011). Pretreatment serum concentrations of 25-hydroxyvitamin D and breast cancer prognostic characteristics: a case-control and a case-series study. PLoS One, 6, 17251. https://doi.org/10.1371/journal.pone.0017251

피인용 문헌

  1. Systemic Analysis on Risk Factors for Breast Cancer Related Lymphedema vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6535
  2. Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3391
  3. Association Between Alterations in the Serum 25-Hydroxyvitamin D Status During Follow-Up and Breast Cancer Patient Prognosis vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2507
  4. Vitamin D exposure and Risk of Breast Cancer: a meta-analysis vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-27297-1