Asian Pacific Journal of Cancer Prevention

  • 제15권1호
  • /
  • Pages.29-32
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Expression of Osteopontin in Non-small Cell Lung Cancer and Correlative Relation with Microvascular Density

  • Yu, Ting-Ting (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
  • Han, Zhi-Gang (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
  • Shan, Li (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
  • Tao, Jie (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
  • Zhang, Tao (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
  • Yuan, Shuai-Fei (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
  • Shen, Hong-Li (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University)
  • 발행 : 2014.01.15
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초록

Background and Objective: Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features. Methods: Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment. Results: Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000). Conclusion: OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.

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참고문헌

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  4. Correlation between lung neoplasm and serum level of osteopontin: A meta-analysis vol.4, pp.5, 2016, https://doi.org/10.3892/br.2016.619
  5. Prognostic value of osteopontin in patients with hepatocellular carcinoma vol.97, pp.43, 2018, https://doi.org/10.1097/MD.0000000000012954