참고문헌
- Ramboer, E., T. Vanhaecke, V. Rogiers, and M. Vinken (2013) Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters. Drug Metab. Rev. 45: 196-217. https://doi.org/10.3109/03602532.2012.756010
- Katenz, E., F. W. Vondran, R. Schwartlander, G. Pless, X. Gong, X. Cheng, P. Neuhaus, and I. M. Sauer (2007) Cryopreservation of primary human hepatocytes: the benefit of trehalose as an additional cryoprotective agent. Liver Transpl. 13: 38-45. https://doi.org/10.1002/lt.20921
- Nishimura, M., A. Koeda, Y. Suganuma, E. Suzuki, T. Shimizu, M. Nakayama, T. Satoh, S. Narimatsu, and S. Naito (2007) Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug Metab Pharmacokinet. 22: 178-186. https://doi.org/10.2133/dmpk.22.178
- Noh, J. K., I. K Jang, H. E. Kim, J. E. Lee, M. S. Yang, E. M. Jang, J. H. Lee, H. J. Park, Y. A. Kim, S. K. Lee, and D. H. Lee (2012) Quality and availability evaluation of human hepatocytes isolated from rejected partial livers for toxicology and drug metabolism studies in Korea. Proceedings of Conference of Korean Society of Toxicology. May 31, Seoul, Korea.
- Kim, K. A., W. K. Song, K. R. Kim, and J. Y. Park (2010) Assessment of CYP2C19 genetic polymorphisms in a Korean population using a simultaneous multiplex pyrosequencing method to simultaneously detect the CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles. J. Clin. Pharm. Ther. 35: 697-703. https://doi.org/10.1111/j.1365-2710.2009.01069.x
- Shin, D. J, J. Kwon, A. R. Park, Y. Bae, E. S. Shin, S. Park, and Y. Jang (2012) Association of CYP2C19*2 and *3 genetic variants with essential hypertension in Koreans. Yonsei Med. J. 53:1113-1119. https://doi.org/10.3349/ymj.2012.53.6.1113
- Ministry of Health and Welfare, Korean Network for Organ Sharing (2013) Annual report of the transplant 2012, pp. 14-15. Korean Network for Organ Sharing, Osong, Korea.
- Aasa, J., Y. Hu, G. Eklund, A. Lindgren, P. Baranczewski, J Malmquist, D. Turek, and T. Bueters (2013) Effect of solvents on the time-dependent inhibition of CYP3A4 and the biotransformation of AZD3839 in human liver microsomes and hepatocytes. Drug Metab. Dispos. 41: 159-169. https://doi.org/10.1124/dmd.112.047597
-
Seglen, P. O. (1972) Preparation of rat liver cells: effect of
$Ca^{++}$ on enzymatic dispersion of isolated, perfused liver. Cell Res. 74: 450-454. https://doi.org/10.1016/0014-4827(72)90400-4 - Oh, K. T., C. J. Ahn, B. M. Ahn, B. H. Hyun, J. Y. Choi, and H. M. Kim (1992) Primary culture of human hepatocytes from small size sample. Korean J. Toxicol. 8: 285-302.
- Kim, H. M., S. B. Han, B. H. Hyun, C. J. Ahn, Y. N. Cha, K. S. Jeong, and G. T. Oh (1995) Functional human hepatocytes: isolation from small liver biopsy samples and primary cultivation with liver-specific functions. J. Toxicol. Sci. 20: 565-578. https://doi.org/10.2131/jts.20.5_565
- Lee, D. H., H. H. Yoon, J. H. Lee, K. W. Lee, S. K. Lee, S. K. Kim, J. E. Choi, Y. J. Kim, and J. K. Park (2004) Enhanced liverspecific functions of endothelial cell-covered hepatocyte heterospheroids. Biochem. Eng. J. 20: 181-187. https://doi.org/10.1016/j.bej.2003.07.005
- Jang, W. H., H. I. Kim, W. J. Lee, J. S, C. S. Choi, Y. K. Choi, H. C. Young, K. H. Kim, J. I. Park, K. W. Kim, and Y. I. Yang (2009) Intracellular-type cryopreservation solution improves the cryopreservation outcome of primary human hepatocytes. Tissue Eng. Regen. Med. 6: 909-915.
- Terry, C., R. R. Mitry, S. C. Lehec, P. Muiesan, M. Rela, N. D. Heaton, R. D. Hughes, and A. Dhawan (2005) The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue. Cell Transplant. 14: 585-594. https://doi.org/10.3727/000000005783982765
- Hewitt, N. J., M. J. Lechón, J. B. Houston, D. Hallifax, H. S. Brown, P. Maurel, J. G. Kenna, L. Gustavsson, C. Lohmann, C. Skonberg, A. Guillouzo, G. Tuschl, A. P. Li, E. LeCluyse, G. M. Groothuis, and J. G. Hengstler (2007) Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metabolism Reviews. 39: 159-234. https://doi.org/10.1080/03602530601093489
- Li, A. P., C. Lu, J. A. Brent, C. Pharm, A, Fackett, C. E. Reugg, and P. M. Silber (1999) Cryopreservation human hepatocytes: Characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem. Biol. Interact. 121: 17-35. https://doi.org/10.1016/S0009-2797(99)00088-5
- Gomez-Lechon, M. J., M. T. Donato, J. V. Castell, and R. Jover (2004) Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. Curr. Drug Metab. 5: 443-462. https://doi.org/10.2174/1389200043335414
- Richert, L., M. J. Liguori, C. Abadie, B. Heyd, G. Mantion, N. Halkic, and W. F. Waring (2006) Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating. Drug Metab. Dispos. 34: 870-879. https://doi.org/10.1124/dmd.105.007708
- Sakai, Y., S. Yamagami, and K. Nakazawa (2010) Comparative analysis of gene expression in rat lier tissue and monolayer and spheroid-cultured hepatocytes. Cell Tissues Organs 191: 281-288. https://doi.org/10.1159/000272316
- Dunn J. C, R. G. Tompkins, and M. L. Yarmush (1991) Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol. Prog. 7: 237-245. https://doi.org/10.1021/bp00009a007