Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Development of Metabolic Engineering Strategies for Microbial Platform to Produce Bioplastics

바이오플라스틱 생산 미생물 플랫폼 제작을 위한 대사공학 전략 개발

  • Park, Si Jae (Department of Environmental Engineering and Energy, Myongji University) ;
  • David, Yokimiko (Department of Environmental Engineering and Energy, Myongji University) ;
  • Baylon, Mary Grace (Department of Environmental Engineering and Energy, Myongji University) ;
  • Hong, Soon Ho (Department of Chemical Engineering, University of Ulsan) ;
  • Oh, Young Hoon (Industrial Biochemicals Research Group, Research Center for Biobased Chemistry, Division of Convergence Chemistry, Korea Research Institute of Chemical Technology) ;
  • Yang, Jung Eun (Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Program), Center for Systems and Synthetic Biotechnology, and Institute for the BioCentury, KAIST) ;
  • Choi, So Young (Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Program), Center for Systems and Synthetic Biotechnology, and Institute for the BioCentury, KAIST) ;
  • Lee, Seung Hwan (Industrial Biochemicals Research Group, Research Center for Biobased Chemistry, Division of Convergence Chemistry, Korea Research Institute of Chemical Technology) ;
  • Lee, Sang Yup (Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Program), Center for Systems and Synthetic Biotechnology, and Institute for the BioCentury, KAIST)
  • Received : 2014.03.24
  • Published : 2014.04.10
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Abstract

As the concerns about environmental problems, climate change and limited fossil resources increase, bio-based production of chemicals and polymers from renewable resources gains much attention as one of the promising solutions to deal with these problems. To solve these problems, much effort has been devoted to the development of sustainable process using renewable resources. Recently, many chemicals and polymers have been synthesized by biorefinery process and these bio-based chemicals and plastics have been suggested as strong candidates to substitute petroleum-based products. In this review, we discuss current advances on the development of metabolically engineered microorganisms for the efficient production of bio-based chemicals and polymers.

환경오염, 기후변화, 고갈되어가는 화석원료에 대한 문제를 해결하기 위해 재생가능한 자원으로부터 케미칼 및 고분자 등의 산업자원을 생산하는 친환경 공정개발에 많은 연구가 진행되고 있다. 최근에 재생가능한 바이오매스로부터 다양한 케미칼 및 고분자 등을 생산하는 바이오리파이너리 공정이 많은 관심을 받고 있으며, 석유화학기반산업을 보완 혹은 대체할 가능성이 매우 높은 친환경공정으로 생각되고 있다. 본 총설에서는 바이오리파이너리 공정에 핵심적인 촉매로 사용되고 있는 재조합 미생물의 개발의 최근 동향을 바이오나일론, 바이오폴리에스터의 생산을 위하여 개발되고 있는 재조합 미생물의 대사공학전략을 중심으로 살펴보고자 한다.

Keywords

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