The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse

  • Choi, Woo Jin (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Kim, Seong Keun (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Park, Hee Kuk (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Sohn, Uy-Dong (College of Pharmacy, Chung-Ang University) ;
  • Kim, Wonyong (Department of Microbiology, College of Medicine, Chung-Ang University)
  • Received : 2013.09.25
  • Accepted : 2013.12.31
  • Published : 2014.02.28
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Abstract

Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd's purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin $1{\beta}$ [IL-$1{\beta}$], IL-6, and IL-10), and prostaglandin $E_2$ ($PGE_2$) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti- inflammatory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was $250{\mu}g/ml$ for VRE and $1,000{\mu}g/ml$ for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti-superbacterial properties, and thus it can be used as a functional food or pharmaceutical.

Keywords

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