Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Protective effect of bacteriophages against Salmonella Typhimurium infection in weaned piglets

이유자돈에서 Salmonella Typhimurium 감염에 대한 박테리오파지의 방어 효능

  • 김성재 (강원대학교 수의과대학.동물종합연구소) ;
  • 김재훈 (씨티씨바이오(주)) ;
  • 전수연 (인트론바이오테크놀로지(주)) ;
  • 백형록 (인트론바이오테크놀로지(주)) ;
  • 한정희 (강원대학교 수의과대학.동물종합연구소)
  • Received : 2013.05.20
  • Accepted : 2014.01.27
  • Published : 2014.03.30
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Abstract

Salmonellosis has caused heavy losses in swine industry and implications for public health. Recently, the urgent problem of antibiotic resistance due to multidrug-resistant Salmonella spp. has been on the rise. The use of host-specific bateriophages as a biocontrol is one possible alternative. In this study, clinical signs, growth performance, quantification and detection of antigen, histopathological changes of gastrointestinal tracts were analyzed comparatively in weaned piglets according to administration of bacteriophages and challenge with Salmonella (S.) Typhimurium. Piglets challenged with S. Typhimurium after administered with bacteriophages showed reduced clinical signs, higher growth performance, lower bacterial shedding, lower quantificational value of antigens in intestines, higher V/C ratio and higher the number of goblet cells in intestines than piglets administered without bacteriophage and challenged with S. Typhimurium. These results indicate that feeding contained with bacteriophages has effect to prevent infection of S. Typhimurium in weaned piglets and suggest that a use of bacteriophage can be considered a valid antibiotic alternative.

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References

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