한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제27권1호
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  • Pages.99-104
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  • 2014
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  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
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도라지 물 추출물의 경구 투여가 마우스 면역 세포 활성에 미치는 효과

Effects of Water Extract from Platycodon grandiflorum on Mouse Immune Cell Activation ex vivo by Oral Administration

  • 류혜숙 (상지대학교 보건과학대학 식품영양학과)
  • Ryu, Hye Sook (Dept. of Food and Nutrition, College of Health Sciences, Sangji University)
  • 투고 : 2013.11.04
  • 심사 : 2014.02.07
  • 발행 : 2014.02.28
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초록

Platycodon grandiflorum have been used as a traditional remedy and food source. This study was performed to investigate the immunomodulating effects of Platycodon grandiflorum in mouse, using ex vivo experiments. Six to seven-week old mice were fed ad libitum on a chow diet, and water extract of Platycodon grandiflorum was orally administrated at two different concentractions (50 and 500 mg/kg B.W./day) every other day for four weeks. In ex vivo experiments, the highest proliferation of splenocytes and levels of cytokine (IL-$1{\beta}$, IL-6, TNF-${\alpha}$) production were observed in 500 mg/kg BW/day supplementation group for all three cytokines stimulated by LPS. In conclusion, this study suggests that Platycodon grandiflorum extracts may enhance the immune function by regulating the splenocytes proliferation and cytokine production capacity by activating macrophages in mice.

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참고문헌

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피인용 문헌

  1. Safety and Anticancer Effects of Platycodon grandiflorum Extracts vol.44, pp.4, 2015, https://doi.org/10.3746/jkfn.2015.44.4.516
  2. Anti-Inflammatory Effects of Streamed Platycodon grandiflorum against UVB Radiation-Induced Oxidative Stress in Human Primary Dermal Fibroblast vol.31, pp.4, 2018, https://doi.org/10.9799/ksfan.2018.31.4.495
  3. Platycodon grandiflorum Extract Ameliorates Cyclophosphamide-Induced Immunosuppression in Mice vol.29, pp.4, 2019, https://doi.org/10.17495/easdl.2019.8.29.4.303