Bulletin of the Korean Chemical Society

  • 제35권2호
  • /
  • Pages.345-346
  • /
  • 2014
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors

  • Kim, Mira (Department of Drug Discovery, Hanmi Research Center) ;
  • Jeon, Jiyoung (Department of Drug Discovery, Hanmi Research Center) ;
  • Baek, Jongouk (Department of Drug Discovery, Hanmi Research Center) ;
  • Choi, Jaeyul (Department of Drug Discovery, Hanmi Research Center) ;
  • Park, Eun Ju (Department of Drug Discovery, Hanmi Research Center) ;
  • Song, Jiyeon (Department of Drug Discovery, Hanmi Research Center) ;
  • Bang, Hyojeong (Department of Drug Discovery, Hanmi Research Center) ;
  • Suh, Kwee Hyun (Department of Drug Discovery, Hanmi Research Center) ;
  • Kim, Young Hoon (Department of Drug Discovery, Hanmi Research Center) ;
  • Kim, Jongmin (College of Pharmacy, Chung-Ang University) ;
  • Kim, Doran (College of Pharmacy, Chung-Ang University) ;
  • Min, Kyung Hoon (College of Pharmacy, Chung-Ang University) ;
  • Lee, Kwang-Ok (Department of Drug Discovery, Hanmi Research Center)
  • 투고 : 2013.11.23
  • 심사 : 2013.11.27
  • 발행 : 2014.02.20
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참고문헌

  1. Deschamps, K.; Cromlish, W.; Weicker, S.; Lamontagne, S.; Huszar, S. L.; Gauthier, J. Y.; Mudgett, J. S.; Guimond, A.; Romand, R.; Frossard, N.; Percival, M. D.; Slipetz, D.; Tan, C. M. Am. J. Respir. Cell. Mol. Biol. 2011, 45, 81. https://doi.org/10.1165/rcmb.2009-0392OC
  2. Small, D. M.; Burden, R. E.; Scott, C. J. Clinic. Rev. Bone. Miner. Metab. 2011, 9, 122. https://doi.org/10.1007/s12018-011-9095-5
  3. Riese, R. J.; Mitchell, R. N.; Villadangos, J. A.; Shi, G.-P.; Palmer, J. T.; Karp, E. R.; De Sanctis, G. T.; Ploegh, H. L.; Chapman, H. A. J. Clin. Invest. 1998, 101, 2351. https://doi.org/10.1172/JCI1158
  4. Shi, G.-P.; Villadangos, J. A.; Dranoff, G.; Small, C.; Gu, L.; Haley, K. J.; Riese, R.; Ploegh, H. L.; Chapman, H. A. Immunity 1999,10, 197. https://doi.org/10.1016/S1074-7613(00)80020-5
  5. Clark, A. K.; Grist, J.; Al-Kashi, A.; Perretti, M.; Malcangio, M. Arthritis Rheum. 2012, 64, 2038. https://doi.org/10.1002/art.34351
  6. Palmer, J. T.; Rasnick, D.; Klaus, J. L.; Bromme, D. J. Med. Chem. 1995, 38, 3193. https://doi.org/10.1021/jm00017a002
  7. Link, J. O.; Zipfel, S. Curr. Opin. Drug. Discov. Devel. 2006, 9, 471.
  8. Wiener, J. J. M.; Sun, S.; Thurmond, R. L. Curr. Top. Med. Chem. 2010, 10, 717. https://doi.org/10.2174/156802610791113432
  9. LY3000328 and VBY-036
  10. Kim, M.; Jeon, J.; Song, J.; Suh, K. H.; Kim, Y. H.; Min, K. H.; Lee, K.-O. Bioorg. Med. Chem. Lett. 2013, 23, 3140. https://doi.org/10.1016/j.bmcl.2013.04.023
  11. Ashburn, B. O.; Rathbone, L. K.; Camp, E. H.; Carter, R. G. Tetrahedron 2008, 64, 856. https://doi.org/10.1016/j.tet.2007.10.118
  12. Enzymatic assay for hCat S, hCat B and hCat K was performed using $SensoLyte^{(R)}$ 520 Cathepsin Activity Assay Kit from Anaspec, Inc.
  13. Murata, M.; Miyashita, S.; Yokoo, C.; Tamai, M.; Hanada, K.; Hatayama, K.; Towatari, T.; Nikawa, T.; Katunuma, N. FEBS Lett. 1991, 280, 307. https://doi.org/10.1016/0014-5793(91)80318-W

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