Clinical and Experimental Reproductive Medicine

  • 제41권4호
  • /
  • Pages.151-157
  • /
  • 2014
  • /
  • 2233-8233(pISSN)
  • /
  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
권호 표지
DOI QR코드

DOI QR Code

Association of the neutrophil-to-lymphocyte ratio and CA 125 with the endometriosis score

  • Kim, Seul Ki (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Park, Jung Yeon (Department of Obstetrics and Gynecology, Seoul National University Hospital) ;
  • Jee, Byung Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Suh, Chang Suk (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Kim, Seok Hyun (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
  • 투고 : 2014.11.06
  • 심사 : 2014.12.03
  • 발행 : 2014.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To evaluate the association between the severity of endometriosis and the preoperative neutrophil-to-lymphocyte ratio (NLR) and serum level of cancer antigen 125 (CA 125). Methods: Data were obtained from the medical records of 419 patients who underwent laparoscopic conservative surgery for ovarian endometrioma between April 2005 and March 2013. Each patient's preoperative complete blood count was recorded and the endometriosis score was assessed. Results: The endometriosis score was not associated with either the NLR or the serum level of CA 125. The endometriosis score was negatively related to preoperative hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. The only positive association was between NLR and the patients' age. NLR and preoperative serum anti-M$\ddot{u}$llerian hormone level were found to be negatively related. Conclusion: The severity of endometriosis was not associated with the serum level of CA 125 or the NLR. The presence of a negative correlation between the severity of endometriosis and red blood cell dynamics needs further investigation.

키워드

참고문헌

  1. Giudice LC, Kao LC. Endometriosis. Lancet 2004;364:1789-99. https://doi.org/10.1016/S0140-6736(04)17403-5
  2. Guo SW, Wang Y. The prevalence of endometriosis in women with chronic pelvic pain. Gynecol Obstet Invest 2006;62:121-30. https://doi.org/10.1159/000093019
  3. Halis G, Mechsner S, Ebert AD. The diagnosis and treatment of deep infiltrating endometriosis. Dtsch Arztebl Int 2010;107:446-55.
  4. Amaral VF, Ferriani RA, Sa MF, Nogueira AA, Rosa e Silva JC, Rosa e Silva AC, et al. Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis. Sao Paulo Med J 2006;124:223-7. https://doi.org/10.1590/S1516-31802006000400010
  5. Barbieri RL, Niloff JM, Bast RC Jr, Scaetzl E, Kistner RW, Knapp RC. Elevated serum concentrations of CA-125 in patients with advanced endometriosis. Fertil Steril 1986;45:630-4. https://doi.org/10.1016/S0015-0282(16)49333-7
  6. Koninckx PR, Riittinen L, Seppala M, Cornillie FJ. CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis. Fertil Steril 1992;57:523-30. https://doi.org/10.1016/S0015-0282(16)54894-8
  7. O'Shaughnessy A, Check JH, Nowroozi K, Lurie D. CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis. Obstet Gynecol 1993;81:99-103.
  8. Mol BW, Bayram N, Lijmer JG, Wiegerinck MA, Bongers MY, van der Veen F, et al. The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis. Fertil Steril 1998;70:1101-8. https://doi.org/10.1016/S0015-0282(98)00355-0
  9. Osuga Y, Koga K, Hirota Y, Hirata T, Yoshino O, Taketani Y. Lymphocytes in endometriosis. Am J Reprod Immunol 2011;65:1-10.
  10. Berbic M, Fraser IS. Regulatory T cells and other leukocytes in the pathogenesis of endometriosis. J Reprod Immunol 2011;88:149-55. https://doi.org/10.1016/j.jri.2010.11.004
  11. Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril 2012;98:511-9. https://doi.org/10.1016/j.fertnstert.2012.06.029
  12. Bedaiwy MA, Falcone T, Sharma RK, Goldberg JM, Attaran M, Nelson DR, et al. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod 2002;17:426-31. https://doi.org/10.1093/humrep/17.2.426
  13. Darai E, Detchev R, Hugol D, Quang NT. Serum and cyst fluid levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours. Hum Reprod 2003;18:1681-5. https://doi.org/10.1093/humrep/deg321
  14. Ulukus M, Ulukus EC, Seval Y, Zheng W, Arici A. Expression of interleukin-8 receptors in endometriosis. Hum Reprod 2005;20:794-801. https://doi.org/10.1093/humrep/deh675
  15. Jee BC, Suh CS, Kim SH, Moon SY. Serum soluble CD163 and interleukin-6 levels in women with ovarian endometriomas. Gynecol Obstet Invest 2008;66:47-52. https://doi.org/10.1159/000119091
  16. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, et al. Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med 1999;159:857-63. https://doi.org/10.1164/ajrccm.159.3.9805087
  17. Zahorec R. Ratio of neutrophil to lymphocyte counts: rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5-14.
  18. Bishara S, Griffin M, Cargill A, Bali A, Gore ME, Kaye SB, et al. Pretreatment white blood cell subtypes as prognostic indicators in ovarian cancer. Eur J Obstet Gynecol Reprod Biol 2008;138:71-5. https://doi.org/10.1016/j.ejogrb.2007.05.012
  19. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophillymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181-4. https://doi.org/10.1002/jso.20329
  20. Cho S, Cho H, Nam A, Kim HY, Choi YS, Park KH, et al. Neutrophilto-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis. Fertil Steril 2008;90:2073-9. https://doi.org/10.1016/j.fertnstert.2008.03.061
  21. Yang H, Lang JH, Zhu L, Wang S, Sha GH, Zhang Y. Diagnostic value of the neutrophil-to-lymphocyte ratio and the combination of serum CA-125 for stages III and IV endometriosis. Chin Med J (Engl) 2013;126:2011-4.
  22. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67:817-21. https://doi.org/10.1016/S0015-0282(97)81391-X
  23. Ilhan N, Daglioglu MC, Ilhan O, Coskun M, Tuzcu EA, Kahraman H, et al. Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration. Ocul Immunol Inflamm 2014:1-4.
  24. Bazzi WM, Dejbakhsh SZ, Bernstein M, Russo P. Neutrophil-lymphocyte ratio in small renal masses. ISRN Urol 2014;2014:759253.
  25. Lee DY, Hong SW, Chang YG, Lee WY, Lee B. Clinical significance of preoperative inflammatory parameters in gastric cancer patients. J Gastric Cancer 2013;13:111-6. https://doi.org/10.5230/jgc.2013.13.2.111
  26. Chen FP, Soong YK, Lee N, Lo SK. The use of serum CA-125 as a marker for endometriosis in patients with dysmenorrhea for monitoring therapy and for recurrence of endometriosis. Acta Obstet Gynecol Scand 1998;77:665-70. https://doi.org/10.1034/j.1600-0412.1998.770615.x
  27. Martinez S, Garrido N, Coperias JL, Pardo F, Desco J, Garcia-Velasco JA, et al. Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis. Hum Reprod 2007;22:836-42. https://doi.org/10.1093/humrep/del419
  28. Rosa E Silva AC, Rosa E Silva JC, Ferriani RA. Serum CA-125 in the diagnosis of endometriosis. Int J Gynaecol Obstet 2007;96:206-7. https://doi.org/10.1016/j.ijgo.2006.11.016
  29. Maiorana A, Cicerone C, Niceta M, Alio L. Evaluation of serum CA 125 levels in patients with pelvic pain related to endometriosis. Int J Biol Markers 2007;22:200-2. https://doi.org/10.5301/JBM.2008.5555
  30. Kafali H, Artuc H, Demir N. Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report. Eur J Obstet Gynecol Reprod Biol 2004;116:85-8. https://doi.org/10.1016/j.ejogrb.2004.02.039
  31. Bodur S, Gun I, Alpaslan Babayigit M. The significance of mean platelet volume on diagnosis and management of adenomyosis. Med Glas (Zenica) 2013;10:59-62.
  32. Defrere S, Gonzalez-Ramos R, Lousse JC, Colette S, Donnez O, Donnez J, et al. Insights into iron and nuclear factor-kappa B (NFkappaB) involvement in chronic inflammatory processes in peritoneal endometriosis. Histol Histopathol 2011;26:1083-92.
  33. Defrere S, Lousse JC, Gonzalez-Ramos R, Colette S, Donnez J, Van Langendonckt A. Potential involvement of iron in the pathogenesis of peritoneal endometriosis. Mol Hum Reprod 2008;14:377-85. https://doi.org/10.1093/molehr/gan033
  34. Gonzalez-Ramos R, Defrere S, Devoto L. Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology. Fertil Steril 2012;98:520-8. https://doi.org/10.1016/j.fertnstert.2012.06.021

피인용 문헌

  1. Use of Neutrophil-to-Lymphocyte Ratio Combined With CA-125 to Distinguish Endometriomas From Other Benign Ovarian Cysts vol.23, pp.6, 2016, https://doi.org/10.1177/1933719115620494
  2. CA125 modified by PLT and NLR improves the predictive accuracy of adenomyosis-derived pelvic dense adhesion vol.96, pp.19, 2017, https://doi.org/10.1097/md.0000000000006880
  3. Coagulation Status in Women With Endometriosis vol.25, pp.4, 2018, https://doi.org/10.1177/1933719117718273
  4. Diagnostic value of serum D‐dimer,CA125, and neutrophil‐to‐lymphocyte ratio in differentiating ovarian cancer and endometriosis vol.147, pp.2, 2014, https://doi.org/10.1002/ijgo.12949
  5. Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? vol.19, pp.1, 2014, https://doi.org/10.1186/s12905-019-0860-9
  6. Diagnostic Value of Circulating MicroRNAs for Endometriosis: a Meta-analysis vol.27, pp.3, 2014, https://doi.org/10.1007/s43032-019-00024-5
  7. CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis vol.9, pp.9, 2014, https://doi.org/10.3390/jcm9093035
  8. Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis vol.22, pp.5, 2014, https://doi.org/10.3390/ijms22052295
  9. Usefulness of hematological parameters for differential diagnosis of endometriomas in adolescents/young adults and older women vol.33, pp.2, 2021, https://doi.org/10.1515/ijamh-2018-0078
  10. Evaluating hematological parameters in women with endometriosis vol.41, pp.7, 2021, https://doi.org/10.1080/01443615.2020.1845634