한국해양바이오학회지 (Journal of Marine Bioscience and Biotechnology)

한국해양바이오학회 (The Korean Society for Marine Biotechnology)
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글루코사민-글루타르알데히드 가교결합체의 항균 효과

Effect of Antimicrobial Activity of the Glutaraldehyde Cross-linked Glucosamine

  • 이춘근 (가천대학교 바이오나노학과 의생명과학전공) ;
  • 황유진 (가천대학교 바이오나노대학 생명과학과) ;
  • 박제권 (가천대학교 바이오나노대학 생명과학과)
  • Lee, Choon Geun (Department of Biomedical Science, College of Bio-nano, Gachon University) ;
  • Hwang, You Jin (Department of Life Science, College of Bio-nano, Gachon University) ;
  • Park, Jae Kweon (Department of Life Science, College of Bio-nano, Gachon University)
  • 투고 : 2014.12.05
  • 심사 : 2014.12.15
  • 발행 : 2014.12.31
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초록

This study was investigated the antimicrobial activity of glutaraldehyde cross-linked glucosamine. Glutaraldehyde was used as a cross-linker which specifically combines an amine-group of molecules. To optimize the mixing ratio of glutaraldehyde and glucosamine, mixing ratio was set up 1:1, 2:1, 3:1 and 0.5:1 in molarity, respectively. The optimum mixing ratio of glucosamine and glutaraldehyde was found to be 3:1 using thin layer chromatography based on the production of complex. Glucosamine-glutaraldehyde cross-linked complex (Ggcc) revealed significant antimicrobial activity toward PWG than F1, both microbial strains were isolated from porcine semen as antibiotics resistance bacteria (ARB). These results clearly demonstrate that Ggcc has potential bactericidal activity toward ARB in porcine semen.

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참고문헌

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