Asian Pacific Journal of Cancer Prevention

  • 제15권22호
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  • Pages.9593-9597
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Ursolic Acid Promotes Apoptosis of SGC-7901 Gastric Cancer Cells through ROCK/PTEN Mediated Mitochondrial Translocation of Cofilin-1

  • Li, Rui (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang) ;
  • Wang, Xia (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang) ;
  • Zhang, Xiao-Hong (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang) ;
  • Chen, Hong-Hai (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang) ;
  • Liu, Yan-Dong (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang)
  • 발행 : 2014.12.18
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초록

Ursolic acid, extracted from the traditional Chinese medicine bearberry, can induce apoptosis of gastric cancer cells. However, its pro-apoptotic mechanism still needs further investigation. More and more evidence demonstrates that mitochondrial translocation of cofilin-1 appears necessary for the regulation of apoptosis. Here, we report that ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis. These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.

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참고문헌

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피인용 문헌

  1. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells vol.49, pp.4, 2017, https://doi.org/10.1093/abbs/gmx012
  2. Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer vol.12, pp.4, 2016, https://doi.org/10.3892/ol.2016.5015