Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Quantitative Assessment of Tremor in PD Using a Wearable System on Both Hands

양손에서 웨어러블 시스템을 이용한 파킨슨병의 정량적 진전 평가

  • Lee, Hongji (Interdisciplinary Program in Bioengineering, Seoul National University) ;
  • Kim, Sangkyong (Interdisciplinary Program in Bioengineering, Seoul National University) ;
  • Kim, Hanbyul (Interdisciplinary Program in Bioengineering, Seoul National University) ;
  • Jeon, Hyoseon (Interdisciplinary Program in Bioengineering, Seoul National University) ;
  • Park, Hyeyoung (Department of Neurology, Seoul National University Hospital) ;
  • Jung, Yujin (Department of Neurology, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Jeonghwan (Technology Group, Life Science Technology) ;
  • Jeon, Beomseok (Department of Neurology, Seoul National University Hospital) ;
  • Park, Kwangsuk (Department of Biomedical Engineering, College of Medicine, Seoul National University)
  • 이홍지 (서울대학교 공과대학 협동과정 바이오엔지니어링 전공) ;
  • 김상경 (서울대학교 공과대학 협동과정 바이오엔지니어링 전공) ;
  • 김한별 (서울대학교 공과대학 협동과정 바이오엔지니어링 전공) ;
  • 전효선 (서울대학교 공과대학 협동과정 바이오엔지니어링 전공) ;
  • 박혜영 (서울대학교병원 신경과) ;
  • 정유진 (강동 경희대학교병원 신경과) ;
  • 김정환 ((주)라이프사이언스 테크놀로지) ;
  • 전범석 (서울대학교병원 신경과) ;
  • 박광석 (서울대학교 의과대학 의공학교실)
  • Received : 2014.05.27
  • Accepted : 2014.06.27
  • Published : 2014.08.30
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Abstract

One of the methods for Parkinson's disease(PD) tremor evaluation is the Clinical Tremor Rating Scale(CTRS). However, the method has some limitations that clinician ratings can vary because the scores are subjectively rated. In addition, most researches usually collected data measured on the more affected arm. In this study, we developed a portable wearable system(SNUMAP system) for measuring PD tremor. The SNUMAP system captures 3-dimensional motion using tri-accelerometer and tri-gyroscope on finger and wrist. 40 PD patients participated in resting tremor and postural tremor tasks, while wearing the system on both hands simultaneously. Estimated tremor scores from Leave-One-Out Cross Validation for regression were highly correlated to the average clinician CTRS scores for rest tremor($r^2$ = 0.87, RMSE = 0.48) and postural tremor($r^2$ = 0.82, RMSE = 0.48). Therefore, the quantitative assessment model can improve treatment of PD patients.

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