Journal of the Korean Society of Manufacturing Process Engineers (한국기계가공학회지)

The Korean Society of Manufacturing Process Engineers (한국기계가공학회)
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Development of A New Micro-fabricated AFM Probe for the Measurement of Biomaterials by using the Precision Glass Bead Supply Unit

글래스비드 정밀공급기구에 의한 바이오재료평가용 AFM프로브의 개발

  • Kweon, H.K. (Dept. of Mechatronics, Kumoh National Univ.) ;
  • Lin, J. (Dept. of Mechatronics, Kumoh National Univ.)
  • 권현규 (금오공과대학교 기전공학과) ;
  • 임건 (금오공과대학교 기전공학과)
  • Received : 2014.06.16
  • Accepted : 2014.12.03
  • Published : 2014.12.31
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Abstract

Many different cells types have been found to be highly sensitive to mechanical force imposed by their surroundings. The cellular response to external mechanical forces has very important effects on numerous biological phenomena. In spite of its importance in biological processes, the cell adhesion force remains difficult to measure quantitatively at the cellular level. In this paper, to enhance quantitative measurements of cell adhesive interactions, a new attaching system and a method in which a glass bead can be attached to an AFM cantilever was designed and fabricated, and the degree of range displacement was controlled in the system. In an experiment, the movement of the stage in the attaching system and the attaching process were measured. The effectiveness of this system was confirmed as well in the experiment. In addition, through a commercial AFM system, the spring constant of the modified AFM probe could be measured.

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References

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