The Role of CT as a Preoperative Evaluation of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

갑상선 유두암의 외측 경부림프절 전이에 대한 수술 전 평가로서 CT의 역할

  • Seok, Jungirl (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital) ;
  • Kim, Hyung Gu (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital) ;
  • Kim, Yoonjoong (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital) ;
  • Han, Kyu-Hee (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital) ;
  • Ahn, Soon-Hyun (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital)
  • 석준걸 (서울대학교 의과대학 분당서울대학교병원 이비인후과학교실) ;
  • 김형규 (서울대학교 의과대학 분당서울대학교병원 이비인후과학교실) ;
  • 김윤중 (서울대학교 의과대학 분당서울대학교병원 이비인후과학교실) ;
  • 한규희 (서울대학교 의과대학 분당서울대학교병원 이비인후과학교실) ;
  • 안순현 (서울대학교 의과대학 분당서울대학교병원 이비인후과학교실)
  • Received : 2013.09.15
  • Accepted : 2013.10.25
  • Published : 2013.11.30

Abstract

Background and Objectives : To assess the usefulness of computed tomography image before papillary thyroid cancer surgery, focus on confirmation of lateral cervical lymph node metastasis not detected by ultrasonography. Material and Methods : From January 2008 to May 2009, total 150 patients who had undergone thyroid surgery and been confirmed papillary thyroid cancer pathologically were enrolled. They had taken neck computed tomography following the ultrasonography. Results : Computed tomography had found suspicious metastatic lateral neck lesion in 13 patients. After the image study, lateral neck lymph node dissection had been included in their surgical plan. Of these, only 7 cases were confirmed pathologically lateral neck lymph node metastasis(positive predictive value=0.54). Taken as whole 150 patients, additionally 4.7% of patients confirmed lateral neck lymph node metastasis by preoperative computed tomography. Conclusion : If preoperative ultrasonography was performed precisely, additional benefits that could be achieved by computed tomography were not much.

Keywords

References

  1. Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG, Lee JS. Cancer statistics in Korea: Incidence, mortality, survival and prevalence in 2010. Cancer research and treatment: Official journal of Korean Cancer Association. 2013;45:1-14. https://doi.org/10.4143/crt.2013.45.1.1
  2. Zanotti-Fregonara P, Hindie E, Faugeron I, Moretti JL, Ravasi L, Rubello D et al. Update on the diagnosis and therapy of distant metastases of differentiated thyroid carcinoma. Minerva endocrinologica. 2008;33:313-327.
  3. Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al. Clinical Significance of Metastasis to the Central Compartment from Papillary Microcarcinoma of the Thyroid. World J Surg. 2006;30:91-99. https://doi.org/10.1007/s00268-005-0113-y
  4. Wada N, Duh QY, Sugino K, Iwasaki H, Kameyama K, Mimura T, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas: Frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Annals of Surgery. 2003;237:399-407.
  5. Shindo M, Wu JC, Park EE, Tanzella F. The importance of central compartment elective lymph node excision in the staging and treatment of papillary thyroid cancer. Archives of Otolaryngology--Head & Neck Surgery. 2006;132:650-654. https://doi.org/10.1001/archotol.132.6.650
  6. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. The American Journal of Medicine. 1994;97:418-428. https://doi.org/10.1016/0002-9343(94)90321-2
  7. McHenry CR, Rosen IB, Walfish PG. Prospective management of nodal metastases in differentiated thyroid cancer. The American Journal of Surgery. 1991;162:353-356. https://doi.org/10.1016/0002-9610(91)90147-6
  8. Noguchi S, Murakami N, Yamashita H, Toda M, Kawamoto H. Papillary thyroid carcinoma: Modified radical neck dissection improves prognosis. Archives of Surgery(Chicago, Ill: 1960). 1998;133:276-280.
  9. Shah JP, Loree TR, Dharker D, Strong EW, Begg C, Vlamis V. Prognostic factors in differentiated carcinoma of the thyroid gland. American Journal of Surgery. 1992;164:658-661. https://doi.org/10.1016/S0002-9610(05)80729-9
  10. Jeong HS, Baek CH, Son YI, Choi JY, Kim HJ, Ko YH, et al. Integrated 18F-FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast-enhanced CT. Clinical Endocrinology. 2006;65:402-407. https://doi.org/10.1111/j.1365-2265.2006.02612.x
  11. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid: official journal of the American Thyroid Association. 2009;19:1167-1214. https://doi.org/10.1089/thy.2009.0110
  12. Cheun HO, Kim KH, Kang YI, Kong SK. A Clinical Review of Surgically Treated Thyroid Nodules. J Korean Surg Soc. 1998;54:172-182.
  13. Radecki PD, Arger PH, Arenson RL, Jennings AS, Coleman BG, Mintz MC, et al. Thyroid imaging: Comparison of high-resolution real-time ultrasound and computed tomography. Radiology. 1984;153:145-147. https://doi.org/10.1148/radiology.153.1.6473776
  14. Kim E, Park JS, Son KR, Kim JH, Jeon SJ, Na DG. Preoperative diagnosis of cervical metastatic lymph nodes in papillary thyroid carcinoma: Comparison of ultrasound, computed tomography, and combined ultrasound with computed tomography. Thyroid: Official journal of the American Thyroid Association. 2008;18:411-418. https://doi.org/10.1089/thy.2007.0269
  15. Choi JS, Kim J, Kwak JY, Kim MJ, Chang HS, Kim EK. Preoperative staging of papillary thyroid carcinoma: Comparison of ultrasound imaging and CT. AJR American Journal of Roentgenology. 2009;193:871-878. https://doi.org/10.2214/AJR.09.2386
  16. Nam-Goong IS, Kim HY, Gong G, Lee HK, Hong SJ, Kim WB, et al. Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: Correlation with pathological findings. Clin Endocrinol(Oxf). 2004;60:21-28. https://doi.org/10.1046/j.1365-2265.2003.01912.x
  17. Grebe SK, Hay ID. Thyroid cancer nodal metastases: Biologic significance and therapeutic considerations. Surgical Oncology Clinics of North America. 1996;5:43-63.
  18. Scheumann GF, Gimm O, Wegener G, Hundeshagen H, Dralle H. Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer. World J Surg. 1994;18:559-567; discussion 567-558. https://doi.org/10.1007/BF00353765
  19. Ito Y, Uruno T, Nakano K, Takamura Y, Miya A, Kobayashi K, et al. An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid: Official journal of the American Thyroid Association. 2003;13:381-387. https://doi.org/10.1089/105072503321669875
  20. Chow SM, Law SC, Chan JK, Au SK, Yau S, Lau WH. Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality. Cancer. 2003;98:31-40. https://doi.org/10.1002/cncr.11442
  21. Stephenson BM, Wheeler MH, Clark OH. The role of total thyroidectomy in the management of differentiated thyroid cancer. Current Opinion in General Surgery;1994. p.53-59.