Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-obesity Effect of Soybean Curd Residue Fermented by Genus Aspergillus

Aspergillus 속 미생물에 의한 발효비지의 항비만 효과

  • Lee, Sang-Il (Department of Food, Nutrition and Culinary Arts, Keimyung College) ;
  • Lee, Ye-Kyung (Center for Nutraceutical and Pharmaceutical Materials, Myongji University) ;
  • Kim, Soon-Dong (Center for Nutraceutical and Pharmaceutical Materials, Myongji University) ;
  • Lim, Jong-Hwan (Center for Nutraceutical and Pharmaceutical Materials, Myongji University) ;
  • Suh, Ju-Won (Center for Nutraceutical and Pharmaceutical Materials, Myongji University) ;
  • Lee, In-Ae (Center for Nutraceutical and Pharmaceutical Materials, Myongji University)
  • 이상일 (계명문화대학교 식품영양조리학부) ;
  • 이예경 (명지대학교 농생명바이오식의약소재개발사업단) ;
  • 김순동 (명지대학교 농생명바이오식의약소재개발사업단) ;
  • 임종환 (명지대학교 농생명바이오식의약소재개발사업단) ;
  • 서주원 (명지대학교 농생명바이오식의약소재개발사업단) ;
  • 이인애 (명지대학교 농생명바이오식의약소재개발사업단)
  • Received : 2013.08.02
  • Accepted : 2013.11.07
  • Published : 2013.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

The anti-obesity effect of soybean curd residues (biji) fermented by seven Aspergillus spp. was investigated with obese ICR mice fed a high-fat diet. After inducing obesity by feeding high-fat diet for 5 weeks, animals were fed with a high fat diet supplemented with 2% fermented soybean curd residues for 6 weeks. Total cholesterol, triglyceride, Alanine transaminase, high-density lipoprotein cholesterol, hepatic content of glutathione and lipid peroxide were determined. In the case of body weight, AE4 group showed most prominent decrease (31.33%, P<0.05) and increase of hepatic GSH and ALT demonstrated hyperlipidemia inhibition. From the results, it is concluded that soybean curd residues fermented by Aspergillus spp. has anti-obesity effect and it is thought that fermented soybean curd resides can reduce obesity in human significantly.

고지방식이로 비만을 유도한 ICR 생쥐를 동물 모델로 하여 7종의 Aspergillus속 미생물로 발효시킨 발효비지의 항비만 효과를 조사하였다. 수컷 ICR 생쥐에 5주간 고지방 식이를 실시하여 비만을 유도하고 고지방식이에 발효비지 2%를 첨가하여 6주 동안 사육하였으며, 체중, 섭취량, 혈청 총콜레스테롤, 중성지질, Alanine transaminase과 high-density lipoprotein cholesterol, 간성 glutathione과 lipid peroxide를 측정하였다. 체중의 경우에 AE4 발효 비지를 식이한 군에서 가장 많이 감소 (31.33%, P<0.05)하였고 간성 GSH와 ALT증가로 고지방혈증이 저해되었다. 이상의 결과로부터 Aspergillus속 미생물로 발효시킨 발효비지는 항비만 효과가 있는 것으로 나타났으며, 나아가 인체에서도 유의한 비만개선 작용을 기대할 수 있을 것으로 사료된다.

Keywords

References

  1. SM Grundy "Multi-factorial causation of obesity. Implications for prevention". Am J Clin Nutr 67: 563S-572S, 1998. https://doi.org/10.1093/ajcn/67.3.563S
  2. JW Yun "Possible anti-obesity therapeutics from nature -A review". Phytochem 71: 1625-1641, 2010.) DOI: http://dx.doi.org/10.1016/j.phytochem.2010.07.011
  3. MS Choi, JI Kim, JB Jeong, SB Lee, JN Jeong, HJ Jeong, EW Seo, TY Kim, OJ Kwon, JH Lim "Suppressive effects of by-product extracts from soybean on adipocyte differentiation and expression of obesity-related genes in 3T3-L1 adipocytes". J Life Sci 21: 358-367, 2011. DOI: http://dx.doi.org/10.5352/JLS.2011.21.3.358
  4. SM Yang, Y Wang, Q Zhang, Y. Wang, Y. Z Zhang, "Production of total polyphenol from fermented soybean curd residue by Lentinus edodes". Int J Food Sci Technol 47: 1215-1221, 2012. DOI: http://dx.doi.org/10.1111/j.1365-2621.2012.02961.x
  5. M Machida "Progress of Aspergillus oryzae genomics". Adv Appl Microbial 51: 81-106, 2002. DOI: http://dx.doi.org/10.1016/S0065-2164(02)51002-9
  6. MZ Park, ID Kim, SD Kim "Effect of rice addition on enzyme activities of soybean Meju fermented by Monascus spp". Korean J Postharvest Sci Technol 8: 405-411, 2001.
  7. M Bizukejc M Pawlak, T Boruta, J Gonciarz "Effect of pH on biosynthesis of lovastatin and other secondary metabolites by Aspergillus terreus ATCC 20542". J Biotechnol 162: 253-261, 2012. DOI: http://dx.doi.org/10.1016/j.jbiotec.2012.09.007
  8. WT Fridewald, RI Levy, DS Fredrickson. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
  9. GL Ellman "Tissue sulfhydryl group". Arch Biochem Biophys 82: 70-77, 1959. DOI: http://dx.doi.org/10.1016/0003-9861(59)90090-6
  10. H Ohkawa, N Ohishi, K Yagi "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction". Anal Biochem 95: 248-254, 1979. DOI: http://dx.doi.org/10.1016/0003-2697(79)90738-3
  11. IS Lee, SW Lee, IZ Lee "Effects of tissue cultured ginseng on blood glucose and lipid in streptozotocin-induced diabetic rats". Korean J Food Sci Technol 35: 280-285, 2003.
  12. BH Park, KY Beck, SI Lee, SD Kim "Effect of chitosan-ascorbate containing soyfiber beni-koji on body weight and lipd content of obesity rats aid induced from high fat diet". J East Asian Soc Dietary Life 16: 663-669, 2006.
  13. RS Wang, T Nakajima, T Honma "Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferase in chemically induced liver damage in rat". Ind Health 37: 440-448, 2000. DOI: http://dx.doi.org/10.2486/indhealth.37.440
  14. MH Kang, JH Lee, JS Lee, JH Kim, HK Chung "Effect of acorn supplementation on lipid profiles and antioxidant enzyme activities in high fat diet-induced obese rats". The Kor Nutr Soc 37: 169-175, 2004.