Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Effects of Hot-Water Extract of Mulberry Leaf Tea Fermented by Monascus pilosus on Body Weight and Hepatic Antioxidant Enzyme Activities in Mouse Fed a Normal Diet

정상식이 마우스의 체중과 간 조직 항산화계 효소활성에 미치는 Monascus pilosus 발효 뽕잎차 열수추출물의 효과

  • Lee, Sang-Il (Department of Food, Nutrition and Culinary Arts, Keimyung College) ;
  • Lee, Ye-Kyung (Division of Bioscience and Bioinformatics, Myongji University) ;
  • Kim, Soon-Dong (Division of Bioscience and Bioinformatics, Myongji University) ;
  • Lee, In-Ae (Division of Bioscience and Bioinformatics, Myongji University) ;
  • Choi, Jongkeun (Department of Cosmetic Science, Chungwoon University) ;
  • Suh, Joo-Won (Division of Bioscience and Bioinformatics, Myongji University)
  • 이상일 (계명문화대학 식품영양조리학부) ;
  • 이예경 (명지대학교 생명과학정보학부) ;
  • 김순동 (명지대학교 생명과학정보학부) ;
  • 이인애 (명지대학교 생명과학정보학부) ;
  • 최종근 (청운대학교 화장품과학과) ;
  • 서주원 (명지대학교 생명과학정보학부)
  • Received : 2013.05.10
  • Accepted : 2013.11.07
  • Published : 2013.11.30
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Abstract

In this study, to evaluate the anti-obesity effects of mulberry leaf tea and its fermented product by Monascus pilosus, we investigated body and organ weight, blood and liver biomarkers in mice fed 1% tea infusions instead of water for 8 weeks. Mice were divided into three groups such as a normal control (NC), unfermented mulberry leaf tea infusion (UMI) and fermented mulberry leaf tea infusion (FMI). Although it is not significant, tea infusion groups showed reduction of body weight gains compared with NC group. Moreover, contents of LDL-cholesterol and lipid peroxide (LPO), altherogenic index, and xanthin oxidase (XO) activity were significantly decreased, and glutathione S-transferase (GST) activity was significantly elevated. The results from this study suggested that UMI and FMI may have an anti-obesity activity, upregulate antioxidant enzymes and reduce levels of oxidants related to liver damage.

본 연구에서는 뽕잎차와 Monascus pilosus로 발효시킨 뽕잎차가 ICR mouse의 체중과 간 조직 항산화계 효소류의 활성에 미치는 영향을 조사하고자 음용수 대신 1% 열수 추출액을 8주간 급여하고 체중, 장기중량, 혈액 및간기능 바이오 마커들의 변화를 관찰하였다. Mice는 뽕잎차(UMI)와 발효뽕잎차의 열수추출액 급여군(FMI) 및 정상대조군(NC) 등 3개군으로 나누었다. 차 추출액을 급여한 군들은 유의한 차이는 보이지 않았으나 NC군에 비하여 체중 증가량이 감소하였고, LDL-콜레스테롤, 동맥경화 지수는 유의한 수준의 감소를 보였으며, 간 조직의 lipid peroxide (LPO) 함량 및 xanthin oxidase (XO) 활성의 감소와 glutathione S-transferase (GST) 활성의 유의적인 증가를 관찰할 수 있었다. 이상의 실험결과, 뽕잎차 및 M. pilosus로 발효시킨 뽕잎차는 체중감소 효과가 있으며 간 조직 손상과 관련된 항산화계 효소의 활성을 높여주는 효과가 있는 것으로 사료된다.

Keywords

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