Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model

  • Yang, Goeun (College of Veterinary Medicine, Chungbuk National University) ;
  • Park, Dongsun (College of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Sun Hee (College of Veterinary Medicine, Chungbuk National University) ;
  • Bae, Dae-Kwon (College of Veterinary Medicine, Chungbuk National University) ;
  • Yang, Yun-Hui (College of Veterinary Medicine, Chungbuk National University) ;
  • Kyung, Jangbeen (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Dajeong (College of Veterinary Medicine, Chungbuk National University) ;
  • Choi, Ehn-Kyoung (College of Veterinary Medicine, Chungbuk National University) ;
  • Hong, Jin Tae (College of Pharmacy, Chungbuk National University) ;
  • Jeong, Heon-Sang (Department Food Science and Technology, Chungbuk National University) ;
  • Kim, Hee Jung (Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University) ;
  • Jang, Su Kil (Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University) ;
  • Joo, Seong Soo (Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University) ;
  • Kim, Yun-Bae (College of Veterinary Medicine, Chungbuk National University)
  • Received : 2013.09.02
  • Accepted : 2013.10.18
  • Published : 2013.11.30
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Abstract

The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitricoxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.

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References

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