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Effects of Polymers on the Cocrystallization of Adefovir Dipivoxil and Suberic Acid

고분자를 이용한 Adefovir Dipivoxil과 Suberic Acid의 공결정 제어

  • Jung, Sungyup (Department of Chemical Engineering, Soongsil University) ;
  • Kim, Il Won (Department of Chemical Engineering, Soongsil University)
  • 정성엽 (숭실대학교 화학공학과) ;
  • 김일원 (숭실대학교 화학공학과)
  • Received : 2013.06.24
  • Accepted : 2013.07.03
  • Published : 2013.09.25

Abstract

The effects of polymers on the cocrystallization of adefovir dipivoxil (AD) and suberic acid (SUB) were investigated. The polymeric additives in the present study were poly(ethylene glycol) (PEG) and poly(acrylic acid) (PAA). When the polymers were added to the solution of AD and SUB, their effects were limited to the morphology and crystallinity of the AD/SUB cocrystal, which could be also achieved without polymeric additives by the excess amount of SUB in the solution or through the solvent-assisted grinding. When the polymers were mixed with AD before adding SUB in the solution, PEG was dramatically more effective at the same amount with possible alteration of the cocrystal structure. Also, PAA completely inhibited the formation of crystals. The present study demonstrated that the effects of polymers on the cocrystallization could be tuned by simply modifying the mixing strategy.

고분자가 adefovir dipivoxil(AD)과 suberic acid(SUB)의 공결정 형성에 미치는 영향을 연구하였다. 고분자 첨가제는 poly(ethylene glycol)(PEG)과 poly(acrylic acid)(PAA)를 이용하였다. 용액에서 AD와 SUB를 혼합한 후에 고분자를 첨가하여 공결정을 제조했을 때는, 고분자의 영향은 결정모양과 결정성을 일부 변화시키는 것에 한정되었는데, 이러한 영향은 고분자 없이도 용액에 과량의 SUB를 이용하거나 용매첨가 분쇄법으로 유도할 수 있었다. 한편, 용액에서 AD와 고분자를 혼합한 후에 SUB를 첨가하여 공결정을 제조했을 때는, PEG의 경우 공결정의 변화를 훨씬 효과적으로 유도하였는데 결정성을 기준으로 같은 농도에서 3배 이상의 효과를 보였다. 또한 PAA의 경우에는 결정의 형성을 완전히 억제하는 효과를 보였다. 본 연구의 결과는 공결정 형성에 미치는 고분자의 영향을 단순히 혼합순서를 바꾸어서 조율할 수 있는 예를 보여 주었다.

Keywords

Acknowledgement

Supported by : 한국에너지기술평가원(KETEP)

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