Journal of Trauma and Injury

The Korean Society of Traumatology (대한외상학회)
권호 표지

Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats

쥐의 파라쿼트 중독 모델에서 설포라판의 영향

  • Jang, Gui-Sang (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Jae-Hyuk (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Kyuseok (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Jo, You Hwan (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Rhee, Joong Eui (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Kyoungbun (Department of Pathology, Seoul National University Hospital) ;
  • Park, Chan Jong (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Kang, Chang Woo (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Soohoon (Department of Emergency Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Joonghee (Department of Emergency Medicine, Seoul National University Bundang Hospital)
  • 장귀상 (분당서울대학교병원 응급의학과) ;
  • 이재혁 (분당서울대학교병원 응급의학과) ;
  • 김규석 (분당서울대학교병원 응급의학과) ;
  • 조유환 (분당서울대학교병원 응급의학과) ;
  • 이중의 (분당서울대학교병원 응급의학과) ;
  • 이경분 (서울대학교병원 병리과) ;
  • 박찬종 (분당서울대학교병원 응급의학과) ;
  • 강창우 (분당서울대학교병원 응급의학과) ;
  • 이수훈 (분당서울대학교병원 응급의학과) ;
  • 김중희 (분당서울대학교병원 응급의학과)
  • Received : 2012.12.20
  • Accepted : 2013.02.12
  • Published : 2013.06.30
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Abstract

Purpose: Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated. Methods: Paraquat was administered via the tail vein, after which sulforaphane or a vehicle (4% DMSO) was administered intraperitoneally 15 minutes after paraquat administration. Histological injury, lipid peroxidation, plasma cytokine (IL-6, IL-10), and nitric oxide were measured. In addition, the effect of sulforaphane on survival in paraquat-intoxication was observed. Results: Regarding histological injury, lipid peroxidation, and plasma cytokine and nitric-oxide response, sulforaphane administration showed no protective effects in paraquat-intoxicated rats. Rather, it increased mortality (log rank p=0.03) and caused lipid peroxidation, as well as plasma cytokine and nitric-oxide production, to be increased. Conclusion: Sulforaphane had no therapeutic effect on paraquat-intoxicated rats; rather, it increased mortality.

Keywords

References

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