DOI QR코드

DOI QR Code

Modic Degenerative Marrow Changes in the Thoracic Spine : A Single Center Experience

  • Lee, Jae Meen (Department of Neurosurgery, Medical Research Institute, Pusan National University Hospital) ;
  • Nam, Kyoung Hyup (Department of Neurosurgery, Medical Research Institute, Pusan National University Hospital) ;
  • Lee, In Sook (Department of Radiology, Medical Research Institute, Pusan National University Hospital) ;
  • Park, Se Kyung (Department of Radiology, Medical Research Institute, Pusan National University Hospital) ;
  • Choi, Byung Kwan (Department of Neurosurgery, Medical Research Institute, Pusan National University Hospital) ;
  • Han, In Ho (Department of Neurosurgery, Medical Research Institute, Pusan National University Hospital)
  • 투고 : 2013.01.17
  • 심사 : 2013.07.17
  • 발행 : 2013.07.28

초록

Objective : The purposes of this study were to evaluate the prevalence, types, and locations of Modic changes (MCs) in the thoracic spine in a large number of subjects, and to investigate the relation between the distributions of MCs and disc herniations (DHs) in the thoracic spine. Methods : Two experienced musculoskeletal radiologists assessed the presence of MCs and DHs by consensus in the thoracic MRIs of 144 patients with non-specific back pain. Patient ages ranged from 22 to 88 years (mean=$53.3{\pm}14.66$ years), and 72 were female (50%). The prevalence, distribution, relation of MCs and DHs was recorded. Results : MC was observed in 8 of the 144 patients (5.6%) and 10 of 1728 segments (0.58%). The most common MC was type II. Of the 8 patients exhibiting MC, 6 had type II (75.0%), and 2 had mixed MCs (type I/II or type II/III). MCs were distributed mainly at the mid-thoracic level (from T5/6 to T9/10). DH was detected in 18 patients (12.5%), 36 of 1728 segments (2.1%). Of the 10 segments exhibiting MC, 5 had DHs at the same level (50.0%). Accordingly, DH was strongly associated with MC (p=0.000). Conclusion : A low prevalence of MC was observed in the thoracic spine, and type II MC predominated. The low prevalence of MC in the thoracic spine suggests that it was caused by a relative lack of mobility as compared with the cervical and lumbar spines. And DHs were found to be strongly associated with MCs even in the thoracic spine.

키워드

참고문헌

  1. Albert HB, Manniche C : Modic changes following lumbar disc herniation. Eur Spine J 16 : 977-982, 2007 https://doi.org/10.1007/s00586-007-0336-8
  2. Braithwaite I, White J, Saifuddin A, Renton P, Taylor BA : Vertebral end-plate (Modic) changes on lumbar spine MRI : correlation with pain reproduction at lumbar discography. Eur Spine J 7 : 363-368, 1998 https://doi.org/10.1007/s005860050091
  3. Fujimori T, Iwasaki M, Nagamoto Y, Ishii T, Kashii M, Murase T, et al. : Kinematics of the thoracic spine in trunk rotation : in vivo 3-dimensional analysis. Spine (Phila Pa 1976) 37 : E1318-E1328, 2012 https://doi.org/10.1097/BRS.0b013e318267254b
  4. Girard CJ, Schweitzer ME, Morrison WB, Parellada JA, Carrino JA : Thoracic spine disc-related abnormalities : longitudinal MR imaging as sessment. Skeletal Radiol 33 : 216-222, 2004 https://doi.org/10.1007/s00256-003-0736-8
  5. Jensen RK, Leboeuf-Yde C, Wedderkopp N, Sorensen JS, Jensen TS, Manniche C : Is the development of Modic changes associated with clinical symptoms? A 14-month cohort study with MRI. Eur Spine J 21 : 2271-2279, 2012 https://doi.org/10.1007/s00586-012-2309-9
  6. Jensen TS, Karppinen J, Sorensen JS, Niinimaki J, Leboeuf-Yde C : Vertebral endplate signal changes (Modic change) : a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J 17 : 1407-1422, 2008 https://doi.org/10.1007/s00586-008-0770-2
  7. Kjaer P, Leboeuf-Yde C, Korsholm L, Sorensen JS, Bendix T : Magnetic resonance imaging and low back pain in adults : a diagnostic imaging study of 40-year-old men and women. Spine (Phila Pa 1976) 30 : 1173-1180, 2005 https://doi.org/10.1097/01.brs.0000162396.97739.76
  8. Luoma K, Vehmas T, Grönblad M, Kerttula L, Kaapa E : MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients. Eur Spine J 17 : 1300-1308, 2008 https://doi.org/10.1007/s00586-008-0716-8
  9. Malinin T, Brown MD : Changes in vertebral bodies adjacent to acutely narrowed intervertebral discs : observations in baboons. Spine (Phila Pa 1976) 32 : E603-E607, 2007 https://doi.org/10.1097/BRS.0b013e31815574e7
  10. Mann E, Peterson CK, Hodler J : Degenerative marrow (modic) changes on cervical spine magnetic resonance imaging scans : prevalence, inter- and intra-examiner reliability and link to disc herniation. Spine (Phila Pa 1976) 36 : 1081-1085, 2011 https://doi.org/10.1097/BRS.0b013e3181ef6a1e
  11. Mitra D, Cassar-Pullicino VN, McCall IW : Longitudinal study of vertebral type-1 end-plate changes on MR of the lumbar spine. Eur Radiol 14 : 1574-1581, 2004
  12. Modic MT, Ross JS : Lumbar degenerative disk disease. Radiology 245 : 43-61, 2007 https://doi.org/10.1148/radiol.2451051706
  13. Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR : Degenerative disk disease : assessment of changes in vertebral body marrow with MR imaging. Radiology 166 (1 Pt 1) : 193-199, 1988 https://doi.org/10.1148/radiology.166.1.3336678
  14. Panjabi MM, Oxland T, Takata K, Goel V, Duranceau J, Krag M : Articular facets of the human spine. Quantitative three-dimensional anatomy. Spine (Phila Pa 1976) 18 : 1298-1310, 1993 https://doi.org/10.1097/00007632-199308000-00009
  15. Peterson CK, Humphreys BK, Pringle TC : Prevalence of modic degenerative marrow changes in the cervical spine. J Manipulative Physiol Ther 30 : 5-10, 2007 https://doi.org/10.1016/j.jmpt.2006.11.013
  16. Ross JS, Perez-Reyes N, Masaryk TJ, Bohlman H, Modic MT : Thoracic disk herniation : MR imaging. Radiology 165 : 511-515, 1987 https://doi.org/10.1148/radiology.165.2.3659375
  17. Toyone T, Takahashi K, Kitahara H, Yamagata M, Murakami M, Moriya H : Vertebral bone-marrow changes in degenerative lumbar disc disease. An MRI study of 74 patients with low back pain. J Bone Joint Surg Br 76 : 757-764, 1994
  18. Wagner AL, Murtagh FR, Arrington JA, Stallworth D : Relationship of Schmorl's nodes to vertebral body endplate fractures and acute endplate disk extrusions. AJNR Am J Neuroradiol 21 : 276-281, 2000
  19. Wang Y, Videman T, Battié MC : Modic changes : prevalence, distribution patterns, and association with age in white men. Spine J 12 : 411-416, 2012 https://doi.org/10.1016/j.spinee.2012.03.026
  20. Wu HL, Ding WY, Shen Y, Zhang YZ, Guo JK, Sun YP, et al. : Prevalence of vertebral endplate modic changes in degenerative lumbar scoliosis and its associated factors analysis. Spine (Phila Pa 1976) 37 : 1958-1964, 2012 https://doi.org/10.1097/BRS.0b013e31825bfb85

피인용 문헌

  1. An Animal Model of Modic Changes by Embedding Autogenous Nucleus Pulposus inside Subchondral Bone of Lumbar Vertebrae vol.6, pp.None, 2013, https://doi.org/10.1038/srep35102
  2. Dorsalgias vol.54, pp.2, 2021, https://doi.org/10.1016/s1286-935x(21)45251-2