대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

후박의 항우울 효과에 대한 실험적 연구

Experimental Study on the Antidepressant Effects of Magnolia Officinalis Extracts

  • 유주연 (원광대학교 한의과대학 내과학교실) ;
  • 우찬 (원광대학교 한의과대학 내과학교실) ;
  • 정혜련 (원광대학교 한의과대학 내과학교실) ;
  • 최정훈 (함소아 한의원) ;
  • 이언정 (원광대학교 한의과대학 내과학교실)
  • You, Ju-Yeon (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Woo, Chan (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Jeong, Hye-Ryon (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Choi, Jung-Hoon (Hamsoa Oriental Medical Clinic) ;
  • Lee, Un-Jung (Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University)
  • 발행 : 2013.09.30
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초록

Objectives : The purpose of this study was to investigate the protective effects of Magnolia Officinalis extracts on the animal model of depression induced by immobilization stress. Methods : The subjects were divided into 4 groups : normal, saline solution-administered during immobilization stress, 200 mg/kg of magnolia extracts-administered (magnolia extract 200), and 400 mg/kg of magnolia extracts- administered (magnolia extract 400). During 2 days of immobilization stress treatment, they underwent forced swimming test (FST) and tail suspension test (TST). The number of serotonin (5-HT) immunostained nuclei in the dorsal raphe nucleus regions was measured by immunohistochemistry. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) in blood were measured. Results : In FST, magnolia-administered groups showed significantly decreased immobilization. In TST, the magnolia extract 400 group showed decreased immobilization. The stress group showed significantly decreased number of 5-HT immunostained nuclei in the dorsal raphe nucleus regions, while magnolia extract 400 group showed increased number of 5-HT immunostained nuclei. Stress group showed decrease in serum level of SOD and GPX, while the magnolia extract 200 group showed increase in serum level of SOD and GPX. Conclusions : These results suggest potent effectiveness of magnolia extracts in the treatment of depression.

키워드

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