한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제30권5호
  • /
  • Pages.359-362
  • /
  • 2013
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

한국내 말티즈에서 발생한 제 1형 폰 빌레브란트병 증례

Type I von Willebrand Disease in a Maltese

  • 김승곤 (건국대학교 수의과대학 내과학교실) ;
  • 강민희 (건국대학교 수의과대학 내과학교실) ;
  • 이교임 (건국대학교 수의과대학 내과학교실) ;
  • 김하정 (플로리다 주립대학교 수의과대학 소동물 임상연구) ;
  • 박희명 (건국대학교 수의과대학 내과학교실)
  • Kim, Seung-Gon (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Min-Hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, Kyo-Im (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ha-Jung (Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 심사 : 2013.10.23
  • 발행 : 2013.10.31
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초록

6살령의 중성화된 숫컷 말티즈(4.16 kg)가 2일전 스켈링과 발치를 실시한 후 지속적인 구강내 출혈로 본원에 내원하였다. 환축은 폰 빌레브란트 인자 항원 평가 결과 54% (정상 범위 70%에서 180%)였으며, 유전된 폰 빌레브란트병를 가진 동형접합체로 판정되었다. 초기 치료를 위해 신선 전혈 수혈을 실시하였다. 수혈 후 환축은 임상증상이 개선되었으며 현재까지 건강한 상태이다. 본 증례는 한국내 말티즈에서 발생한 제 1형 폰 빌레브란트병의 첫 번째 진단 보고이다.

A 6-year-old castrated male Maltese weighing 4.16 kg presented with a history of bleeding from the mouth after scaling and dental extraction 2 days prior. The von Willebrand factor antigen (vWf:Ag) level was 54% (reference range, 70-180%), indicating that the dog was homozygous for an inherited von Willebrand disease (vWD). The dog received whole-blood transfusion as initial treatment, consequently showing markedly improved clinical signs, and is currently in good condition. To our knowledge, this is the first reported case of type 1 vWD in a Maltese in Korea.

키워드

참고문헌

  1. Brooks M. von Willebrand disease. Schalm's Veterinary Hematology. 5th ed. Philadelphia: Lippincott Williams and Wilkins 2000; 509-515.
  2. Brooks M, Catalfamo J. Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thromb Haemost 1993; 70: 777-780.
  3. Brooks M, Catalfamo J. Platelet disorders and von Willebrand disease. In : Textbook of veterinary internal medicine. 6th ed. St Louis: Elsevier 2005: 1918-1929.
  4. Budde U, Schneppenheim R. Von willebrand factor and von willebrand disease. Rev Clin Exp Hematol 2001; 5: 335-335. https://doi.org/10.1046/j.1468-0734.2001.00048.x
  5. De Gopegui RR, Feldman BF. von Willebrand's disease. Comp Clin Path 1997; 7: 187-196.
  6. Edwards MJ, Mulley RC. Genetic, Development, and Neoplastic Diseases. In: Diseases of Swine. Ames: Iowa State Press 1999; 706.
  7. Elizabeth V. Disorder of erythrocytes. In : BSAVA Manual of Canine and Feline Clinical Pathology. 2nd ed. Gloucester, UK: British Small Animal Veterinary Association 2005: 33-57.
  8. Federici AB, Castaman G, and Mannucci PM. Guidelines for the diagnosis and management of von Willebrand disease in Italy. Haemophilia 2002; 8: 607-621. https://doi.org/10.1046/j.1365-2516.2002.00672.x
  9. Mattoso CRS, Takahira RK, Beier SL, Araújo JP, Corrente JE. Prevalence of von Willebrand disease in dogs from Sao Paulo State, Brazil. J Vet Diagn Invest 2010; 22: 55-60. https://doi.org/10.1177/104063871002200109
  10. Johnstone IB. Canine von Willebrand's disease: A common inherited bleeding disorder in Doberman Pinscher dogs. Can Vet J 1986; 27: 315-318.
  11. Lewis JH, Spero JA, Hasiba U. A hemophiliac dog colony: Genetic studies and coagulation findings in hemophiliac and normal dogs. Comp Biochem Physiol 1983; 75: 147-151. https://doi.org/10.1016/0300-9629(83)90061-0
  12. Littlewood JD. von Willebrand's disease in the dog. Vet Annual 1991; 31: 163-172.
  13. Littlewood JD, Herrtage ME, Gorman NT, Mc Glennon NJ. von Willebrand's disease in dogs in the United Kingdom. Vet Rec 1987; 121: 463-468. https://doi.org/10.1136/vr.121.20.463
  14. Mannucci PM. Desmopressin: a nontransfusional form of treatment for congenital and acquired disorders. Blood 1988; 72: 1449-1455.
  15. Meyers LJ, Pierce KR, Growing GM, Leonpacher RJ. Hemorrhagic diathesis resembling pseudohemophilia in a dog. J Am Vet Med Assoc 1972; 161: 1028-1029.
  16. Meyers KM, Wardrop KJ, Meinkoth J. Canine von Willebrand's disease: Pathobiology, diagnosis, and short-term treatment. Compend Contin Educ Pract Vet 1992; 14: 13-22.
  17. Raymond SL, Jones DW, Brooks MB, Dodds WJ. Clinical and laboratory features of a severe form of von Willebrand's disease in Shetland sheepdogs. J Am Vet Med Assoc 1990; 197: 1342-1346.
  18. Schwarz HP, Schlokat U, Mitterer A, Váradi K, Gritsch H, Eva-Maria Muchitsch EM, Auer W, Pichler L, Dorner F, Turecek PL. Recombinant von Willebrand Factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease. Semin Thromb Hemost 2002; 28: 215-226. https://doi.org/10.1055/s-2002-27823
  19. Stokol T, Parry BW, Mansell PD. von Willebrand's disease in Scottish Terriers in Australia. Aust Vet J 1995; 72: 404-407. https://doi.org/10.1111/j.1751-0813.1995.tb06188.x
  20. Thomas JS. von Willebrand's disease in the dog and cat. Vet Clin N Am: Small Anim Pract 1996; 26: 1089-1107. https://doi.org/10.1016/S0195-5616(96)50057-4
  21. Tracy S. Disorders of haemostasis. In : BSAVA Manual of Canine and Feline Clinical Pathology. 2nd ed. Gloucester, UK: British Small Animal Veterinary 2005: 83-98.
  22. Turrentine MA. Kraus KH. Johnson GS. Plasma from donor dogs, pretreated with DDAVP, transfused into a German Shorthair Pointer with type II von Willebrand's disease. Vet Clin North Am Small Anim Pract 1988; 18: 275.