Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Effect of Electron-beam Irradiaton on the Artificial Bone Substitutes Composed of Hydroxyapatite and Tricalcium Phosphate Mixtures with Type I Collagen

수산화인회석과 인산삼칼슘 및 1형 콜라젠 혼합골의 전자빔 조사 효과

  • Park, Jung Min (Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Kim, Soung Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Kim, Min Keun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Park, Young Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Myoung, Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Byung Cheol (Quantum Optics Laboratory, Korea Atomic Research Institute) ;
  • Lee, Jong Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Suk Keun (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University)
  • 박정민 (서울대학교 치의학대학원 치학연구소) ;
  • 김성민 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 김민근 (강릉원주대학교 치과대학 구강악안면외과학교실) ;
  • 박영욱 (강릉원주대학교 치과대학 구강악안면외과학교실) ;
  • 명훈 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 이병철 (한국원자력연구원 양자과학기술개발부) ;
  • 이종호 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 이석근 (강릉원주대학교 치과대학 구강병리학교실)
  • Received : 2012.11.05
  • Accepted : 2013.01.24
  • Published : 2013.01.31
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Abstract

Purpose: The aim of this study is to evaluate the effect and potential of electron beam (E-beam) irradiation treatment to the synthetic bony mixtures composed of hydroxyapatite (HA; Bongros$^{(R)}$, Bio@ Co., Korea) and tricalcium phosphate (${\beta}$-TCP, Sigma-Aldrich Co., USA), mixed at various ratios and of type I collagen (Rat tail, BD Biosciences Co., Sweden) as an organic matrix. Methods: We used 1.0~2.0 MeV linear accelerator and 2.0 MeV superconductive linear accelerator (power 100 KW, pressure 115 kPa, temperature $-30{\sim}120^{\circ}C$, sensor sensitivity 0.1~1.2 mV/kPa, generating power sensitivity 44.75 mV/kPa, supply voltage $5{\pm}0.25$ V) with different irradiation dose, such as 1, 30 and 60 kGy. Structural changes in this synthetic bone material were studied in vitro, by scanning electron microscopy (SEM), elementary analysis and field emission scanning electron microscope (FE-SEM), attenuated total reflection (ATR), and electron spectroscopy for chemical analysis (ESCA). Results: The large particular size of HA was changed after E-beam irradiation, to which small particle of TCP was engaged with organic collagen components in SEM findings. Conclusion: The important new in vitro data to be applicable as the substitutes of artificial bone materials in dental and medical fields will be able to be summarized.

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References

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