Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Potential Therapeutic Efficacy of Curcumin in Liver Cancer

  • Dai, Xin-Zheng (Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health) ;
  • Yin, Hai-Tao (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University) ;
  • Sun, Ling-Fei (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University) ;
  • Hu, Xiang (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University) ;
  • Zhou, Chong (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University) ;
  • Zhou, Yun (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University) ;
  • Zhang, Wei (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University) ;
  • Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research) ;
  • Li, Xiang-Cheng (Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health)
  • Published : 2013.06.30
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Abstract

Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.

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References

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