Journal of Microbiology and Biotechnology

  • 제23권7호
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  • Pages.1023-1030
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  • 2013
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Lipoteichoic Acid Suppresses Effector T Cells Induced by Staphylococcus aureus-Pulsed Dendritic Cells

  • Son, Young Min (Animal Science and Biotechnology Major, Department of Agricultural Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Song, Ki-Duk (Center for Food and Bioconvergence, Seoul National University) ;
  • Park, Sung-Moo (Animal Science and Biotechnology Major, Department of Agricultural Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Han, Seung Hyun (Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Yun, Cheol-Heui (Animal Science and Biotechnology Major, Department of Agricultural Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University)
  • 투고 : 2013.02.06
  • 심사 : 2013.03.27
  • 발행 : 2013.07.28
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초록

Lipoteichoic acid (LTA), uniquely expressed on gram-positive bacteria, is recognized by Toll-like receptor 2 (TLR2) on not only antigen-presenting cells but also activated T cells. Therefore, it is reasonable to assume that LTA is acting on T cells. However, little is known about the effect of LTA on T-cell regulation. In the present study, we investigated the immunomodulatory effects of LTA on $CD4^+$ T cells. Effector $CD4^+$ T cells, induced after co-culture with S. aureus-pulsed dendritic cells, produced high levels of interferon-${\gamma}$, CD25, CD69, and TLRs 2 and 4. When effector $CD4^+$ T cells were treated with LTA, the expressions of the membrane-bound form of transforming growth factor (TGF)-${\beta}$ and forkhead box P3 increased. Coincidently, the proliferation of effector $CD4^+$ T cells was declined after LTA treatment. When TGF-${\beta}$ signaling was blocked by the TGF-${\beta}$ receptor 1 kinase inhibitor, LTA failed to suppress the proliferation of effector $CD4^+$ T cells. Therefore, the present results suggest that LTA suppresses the activity of effector $CD4^+$ T cells by enhancing TGF-${\beta}$ production.

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