Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Galgunhaejutang on Alcohol Consumption in C57BL/6 Mice

  • Cho, Seung-Hun (Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Medical Center) ;
  • Kim, Hyeun-Kyeung (Medical Research Institute, Pusan National University) ;
  • Kim, Jong-Woo (Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Whang, Wei-Wan (Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Medical Center) ;
  • Kim, Sung-Gon (Department Psychiatry, Pusan National University Yangsan Hospital)
  • Received : 2013.08.09
  • Accepted : 2013.08.27
  • Published : 2013.09.30
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Abstract

Objectives : Galgunhaejutang extract (GHT) is a Traditional Korean medical herbal mixture that has been tradtionally used to treat alcohol consumption. This study was preformed to evaluate the effects of GHT on alcohol consumption in C57BL/6 mice. Methods : Sixty three C57BL/6 mice were alcohol dependence-induced by limited access paradigm. Water, GHT 0.688 g/kg (GHT-L), or GHT 3.45 g/kg (GHT-H) were administrated for 10 days. The amounts of alcohol consumption for 2 hours, water consumption for 22 hours, food intake for 24 hours and body weight were measured. Results : There weren't significant differences in 2 hours of alcohol consumption, 22 hours of water consumption, 24 hours of food intake and body weight for ten days between vehicle group and GHT-L or GHT-H group. Conclusions : Further studies employing multi-dose and long term administration of GHT (more than 10 days) might be of benefit.

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References

  1. Bang HY, Whang WW. The Effects of Galgunhaejutang, Danjuhwan and Haejujigaltang on the Experimental Behaviors of Alcohol-Intoxicated Mice. J of Orieantal Neuropsychiatry. 1994;5(1): 93-101.
  2. Keung WM, Vallee BL. Daidzin and Daidzein Suppress Free-Choice Ethanol Intake by Syrian Golden Hamsters. USA Proc Natl Acad Sci. 1993;90(21):10008-12. https://doi.org/10.1073/pnas.90.21.10008
  3. Overstreet DH, Lee YW, Rezvani AH, Pei YH, Criswell HE, Janowsky DS. Suppression of Alcohol Intake after Administration of the Chinese Herbal Medicine, NPI-028, and Its Derivatives. Alcohol Clin Exp Res. 1996;20(2): 221-7. https://doi.org/10.1111/j.1530-0277.1996.tb01633.x
  4. Yoon JT, Kim MJ, Kim SG. Effect of Long-term Administration of Radix Puerariae on Alcohol Craving in the Patients with Alcoholism. J Korean Neuropsychiartr Assoc. 1995;34(6):1937-48.
  5. Kim JH, Kim MJ, Kim SG, Park JM, Jung YI. Effects of Radix Puerariae on Blood Alcohol Concentraion in Healthy Adults. J Korean Neuropsychiartr Assoc. 1996;35(6):1230-5.
  6. Kim MJ, Jung YI, Park JM, Kim SG, Choi YG. Effect of Radix Puerariae on Blood Alcohol Concentration and Alcohol Effects in the Alcoholics. J Korean Neuropsychiartr Assoc. 1996; 35(6):1236-46.
  7. Kang CJ, Kim MJ, Kim SG, Kim IJ. Effect of Radix Puerariae on Alcohol Craving and Regional Cerebral Blood Flow in the Patients with Alcohol Dependence. J Korean Neuropsychiartr Assoc. 1997;36(5):861-9.
  8. Stromberg MF, Casale M, Volpicelli L, Volpicelli JR, O'BRIEN CP. A Comparison of the Effects of the Opioid Antagonists Naltrexone, Naltri-ndole, and $\beta$-Funaltrexamine on Ethanol Consumption in the Rat. Alcohol. 1998;15(4):281-9. https://doi.org/10.1016/S0741-8329(97)00131-6
  9. Le AD, Ko J, Chow S, Quan B. Alcohol Consumption by C57BL/6, BALB/c, and DBA/2 Mice in a Limited Access Paradigm. Pharmacol Biochem Behav. 1994;47(2):375-8. https://doi.org/10.1016/0091-3057(94)90026-4
  10. Le AD, Poulos CX, Quan B, Chow S. The Effects of Selective Blockade of Delta and Mu Opiate Receptors on Ethanol Consumption by C57BL/6 Mice in a Restricted Access Paradigm. Brain Res. 1993;630(1-2):330-2. https://doi.org/10.1016/0006-8993(93)90672-A
  11. Wegelius K, Honkanen A, Korpi ER. Benzodiazepine Receptor Ligands Modulate Ethanol Drinking in Alcohol-Preferring Rats. European Journal of Phamacology. 1994;263(1-2):141-7. https://doi.org/10.1016/0014-2999(94)90534-7