Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Cytotoxicity of Neolignans from Magnolia obovata Fruits

  • Seo, Kyeong-Hwa (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University) ;
  • Lee, Dae-Young (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Jeong, Rak-Hun (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University) ;
  • Yoo, Ki-Hyun (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University) ;
  • Chung, In-Sik (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University) ;
  • Kim, Geum-Soog (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Seo, Woo-Duck (Department of Functional Crop, National Institute of Crop Science, RDA) ;
  • Kang, Hee-Cheol (GFC Co., Ltd.) ;
  • Ahn, Eun-Mi (Department of Herbal Foodceutical Science, Daegu Haany University) ;
  • Baek, Nam-In (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University)
  • Received : 2012.12.24
  • Accepted : 2013.05.30
  • Published : 2013.09.30
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Abstract

Repeated $SiO_2$ and octadecyl silica gel (ODS) column chromatographies of the EtOAc fraction from Magnolia obovata fruits, 10 neolignans, named magnolol (1), honokiol (2), isoobovatol (3), isomagnolol (4), obovatol (5), obovatal (6), 9-methoxyobovatol (7), magnobovatol (8), obovaaldehyde (9), and 2-hydroxyobovaaldehyde (10) were isolated and identified. All isolated compounds were evaluated for in vitro cytotoxicity against seven human cancer cell lines.

Keywords

References

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