Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis

  • Sohn, Ki Cheul (Department of Preventive Medicine, School of Medicine, Catholic University of Daegu) ;
  • Kang, Su Jin (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University) ;
  • Kim, Joo Wan (Glucan Corporation and Marine Bio-Industry Development Center) ;
  • Kim, Ki Young (Glucan Corporation and Marine Bio-Industry Development Center) ;
  • Ku, Sae Kwang (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University) ;
  • Lee, Young Joon (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University)
  • Received : 2013.05.08
  • Accepted : 2013.06.12
  • Published : 2013.07.31
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Abstract

This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate-administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-${\alpha}$, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.

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References

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