폴리머 (Polymer(Korea))

  • 제37권4호
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  • Pages.486-493
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  • 2013
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  • 0379-153X(pISSN)
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  • 2234-8077(eISSN)
한국고분자학회 (The Polymer Society of Korea)
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교대배열 PVA 젤 섬유를 이용한 고분자 색전 코일 제조

Preparation of Coil-Embolic Material Using Syndiotactic Poly(vinyl alcohol) Gel Spun Fibers

  • 서영호 (영남대학교 나노메디컬유기재료공학과) ;
  • 오태환 (영남대학교 나노메디컬유기재료공학과) ;
  • 한성수 (영남대학교 나노메디컬유기재료공학과) ;
  • 주상우 (영남대학교 기계공학부) ;
  • 길명섭 (전북대학교 유기소재파이버공학과)
  • Seo, Young Ho (Department of Nano, Medical and Polymer Materials, Yeungnam University) ;
  • Oh, Tae Hwan (Department of Nano, Medical and Polymer Materials, Yeungnam University) ;
  • Han, Sung Soo (Department of Nano, Medical and Polymer Materials, Yeungnam University) ;
  • Joo, Sang Woo (School of Mechanical Engineering, Yeungnam University) ;
  • Khil, Myeong Seob (Department of Organic Materials and Fiber Engineering, Chonbuk National University)
  • 투고 : 2013.02.06
  • 심사 : 2013.04.29
  • 발행 : 2013.07.25
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초록

고분자 색전 코일을 제조하기 위하여 교대배열 PVA(s-PVA) 용액을 제조하고 젤방사 조건의 최적화를 위해 고분자용액의 유변학적 특성을 분석하였다. 현탁중합을 통해 비누화도 99%, 교대배열기 함량 56%인 s-PVA를 제조하였고 고분자 용액의 농도에 따른 점도 변화 측정을 통해 최적의 방사농도를 13 wt%로 선정하였다. S-PVA 젤 섬유의 연신비에 따른 구조, 형태, 인장 특성을 측정하였다. S-PVA 젤 섬유의 연신비가 증가함에 따라 인장강도가 증가하였고, 최대 연신비인 15배 연신하였을 때 인장강도는 580 MPa이었고 절단신도는 연신비가 증가함에 따라 감소하는 경향을 나타냈다. S-PVA 젤 섬유는 연신비에 따라 결정구조가 발달하고 배향도가 증가하는 경향을 나타내었다. 색전 코일 제조 시의 열처리온도에 따른 코일의 형태 안정성을 살펴 본 결과 열처리온도가 높을수록 코일의 형태안정성이 우수하였으며 금속 색전 코일로 제조되는 1차 코일 및 2차 코일 형태를 s-PVA 섬유를 이용해 제조하였고 이를 통해 금속 색전 코일의 고분자로의 대체 가능성을 확인하였다.

The structure, morphology, and physical properties of syndiotatic poly(vinyl alcohol) (s-PVA) gel spun fibers were investigated to prepare polymeric embolization coils. S-PVA was prepared by saponification of the poly(vinyl acetate)/poly(vinyl pivalate)(PVAc/PVPi) copolymer. The viscosity of s-PVA solutions showed shear thinning behavior and the solution formed a homogeneous phase. Based on shear viscosity change with concentration, the optimum dope concentration was selected as 13 wt%, after which s-PVA fibers were spun and the solvent was removed. The fibers were then drawn with a maximum draw ratio of 15. A polymeric embolization coil was made of the s-PVA gel-spun fibers. The fibers were wound densely onto rigid rod and then annealed at different annealing temperatures. The polymeric embolization coil annealed at $200^{\circ}C$ was similar to metallic coils and its shape was maintained well after extension. Overall, gel-spun PVA fibers performed well for the preparation of primary and secondary coils to replace metallic coils.

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