초록
Background: To quantify changes of left ventricular (LV) torsion in patients' pre and post kidney transplantation. Methods: A prospective study was conducted on 48 patients who received kidney transplantation for end stage renal disease and without myocardial infarction. The rotation, twist and torsion of LV were studied pre and post kidney transplantation (6 months post transplantation) using velocity vector imaging by echocardiography. The data is expressed as mean${\pm}$standard deviation and compared by paired t-test at the p < 0.05 significance level. Results: Six months post kidney transplantation, left ventricular ejection fraction (from $40.33{\pm}11.42$ to $61.00{\pm}13.68%$), ratio of mitral early and late diastolic filling velocity (from $1.04{\pm}0.57$ to $1.21{\pm}0.52$), rotation of basal LV (from $4.48{\pm}2.66$ to $5.65{\pm}2.64degree$), rotation of apical LV (from $4.27{\pm}3.08$ to $5.50{\pm}4.25degree$), LV twist ($8.75{\pm}4.45$ to $11.14{\pm}5.25degree$) and torsion (from $1.06{\pm}0.54$ to $1.33{\pm}0.61degree/cm$) were increased significantly (p < 0.05). Interventricular septum thickness (from $11.67{\pm}2.39$ to $9.67{\pm}0.48mm$), left ventricular mass index (from $104.00{\pm}16.47$ to $95.50{\pm}21.44g/m^2$), systolic blood pressure (from $143.50{\pm}34.99$ to $121.50{\pm}7.09mmHg$), serum blood urea nitrogen (from $42.40{\pm}7.98$ to $30.43{\pm}13.85mg/dL$) and creatinine (from $4.53{\pm}1.96$ to $2.73{\pm}2.57mg/dL$) were decreased significantly (p < 0.05). Conclusion: Kidney transplantation in end stage renal disease without myocardial infarction results in improvement in left ventricular structure, function and myocardial mechanics as detected by echocardiography and velocity vector imaging. Velocity vector imaging provided valuable information for detection and follow-up of cardiac abnormalities in patients with end stage renal disease.