한국산업보건학회지 (Journal of Korean Society of Occupational and Environmental Hygiene)

  • 제23권2호
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  • Pages.50-56
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  • 2013
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  • 2384-132X(pISSN)
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  • 2289-0564(eISSN)
한국산업보건학회 (Korean Industrial Hygiene Association)
권호 표지

산화란타늄, 산화네오디뮴이 세포독성 및 DNA손상에 미치는 영향

Cytotoxicity and DNA Damage in Human Lung Cells Treated with Lanthanum Oxide and Neodymium Oxide

  • 김종규 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 김수진 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 강민구 (산업안전보건연구원 화학물질센터 독성연구팀) ;
  • 정용현 (산업안전보건연구원 화학물질센터 독성연구팀)
  • Kim, Jong Kyu (Toxicity Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Kim, Soo Jin (Toxicity Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Kang, Min Gu (Toxicity Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute) ;
  • Chung, Young Hyun (Toxicity Research Team, Center for Chemicals Safety and Health, Occupational Safety & Health Research Institute)
  • 발행 : 2013.06.30
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The present study investigated cytotoxicity and DNA damage in human lung cells in vitro. Methods: Neodymium oxide and lanthanum oxide were dispersed by ultrasonic treatments. The assay was performed with MRC-5 (Human male fetus lung cell). Cytotoxicity and comet assay of lanthanum oxide and neodymium oxide were measured after 24 and 48 hours incubation. Results: After 24 hours of exposure to rare earth metals, the cytotoxicities of lanthanum oxide in more than $1{\mu}M$ concentration groups were significantly increased when compared to the control group, but the cytotoxicities of neodymiun oxide in more than $100{\mu}M$ concentration groups were statistically increased. After 48 hours exposure, cytotoxicities of both materials were statistically increased in $100,000{\mu}M$ concentration groups. Olive tail moments of the lanthanum oxide treated group were significantly increased when compared to the control group. Conclusions: The cytotoxicity of lanthanum oxide was higher than that of neodymium oxide. The DNA of MRC-5 cells treated with lanthanum oxide for 48 hours were significantly damaged.

키워드

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