Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Swelling Properties for Cross-linking Degree of Hyaluronic Acid Hydrogels

히알루론산 하이드로겔의 가교도에 따른 함수특성

  • Kim, Jin Tae (Department of Advanced Material Engineering, Chungbuk National University) ;
  • Lee, Deuk Yong (Department of Materials Engineering, Daelim University) ;
  • Oh, Yoo Seoung (Department of Prosthetics and Orthotics, Chungbuk Health & Science University) ;
  • Bang, Jung Wan (Department of Advanced Material Engineering, Seoul National University) ;
  • Hyun, Chang-Yong (Department of Advanced Material Engineering, Seoul National University) ;
  • Kim, Tae-Hyung (Department of Radiological Science, Kangwon National University) ;
  • Choi, Jae Ha (Department of Advanced Material Engineering, Chungbuk National University)
  • 김진태 (충북대학교 신소재공학과) ;
  • 이득용 (대림대학교 재료정보과) ;
  • 오유성 (충북보건과학대학교 의기공과) ;
  • 방중완 (서울과학기술대학교 신소재공학과) ;
  • 현창용 (서울과학기술대학교 신소재공학과) ;
  • 김태형 (강원대학교 방사선학과) ;
  • 최재하 (충북대학교 신소재공학과)
  • Published : 2013.03.01
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Abstract

Hyaluronic acid (HA) hydrogels were crosslinked by dropping of sodium hyaluronate solutions into a solution mixture of divinyl sulfone (DVS) dissolved in 2-methyl-1-propanol. Then cleaning for residual unreacted DVS, and drying at $60^{\circ}C$, 20torr vacuum. The experimental conditions are crosslinking temperature (CLT), crosslinking agent concentration (CAC), respectively. And then parametric studied the morphology, the porosity, the swelling ratio of the hydrogels. The swelling ratio and pore size were decreased as the degree of crosslink was increased. They can be controlled by adjusting the by varying CLT and CAC.

Keywords

References

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