Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Drug Release Behavior and Anti-smooth Muscle Cell Proliferation Property of Stent Coating Film Regulated by Biodegradable Polymer Composition

생분해성 고분자 조성에 따른 스텐트 코팅용 필름의 약물 방출 특성 및 평활근 세포 증식 억제 효율 분석

  • Min, Daehong (Department of Biotechnology, The Catholic University of Korea) ;
  • Park, Taehyun (Department of Biotechnology, The Catholic University of Korea) ;
  • Lee, Dong Ki (Department of internal medicine, Gangnam Severance Hospital, Yonsei University, College of Medicine) ;
  • Na, Kun (Department of Biotechnology, The Catholic University of Korea)
  • 민대홍 (가톨릭대학교 생명공학과) ;
  • 박태현 (가톨릭대학교 생명공학과) ;
  • 이동기 (연세대학교 의과대학 강남 세브란스병원 내과학교실) ;
  • 나건 (가톨릭대학교 생명공학과)
  • Published : 2013.03.01
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Abstract

The drug-eluting stent coating film (PTX-Eluting PTFE film) was investigated by using poly(lactic-co-glycolic acid) (PLGA) and poly L-lactic acid (PLLA) via dip coating technique and characterized by thickness, drug eluting test, contact angle, proliferation of smooth muscle cell (SMC). The thickness of the films in ranged from $0.039{\mu}m$ to $0.045{\mu}m$ according to the composition of PLGA and PLLA. The sustained release behavior of paclitaxel (PTX) was observed for 65 days at PLGA:PLLA (3:7) film. The surface degradation behavior of the film exposed for 65 days in PBS buffer depends on the ration of PLLA. For monitoring of restenosis, the attachment and proliferation of SMC on the film was observed by fluorescence microscopy. The attachment and proliferation of SMC increase with increasing of PLLA content. It means that the hydrophilic property of the film surface leads to suppress the attachment and proliferation of SMC.

Keywords

References

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