공업화학 (Applied Chemistry for Engineering)

  • 제24권4호
  • /
  • Pages.416-422
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  • 2013
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  • 1225-0112(pISSN)
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  • 2288-4505(eISSN)
한국공업화학회 (The Korean Society of Industrial and Engineering Chemistry)
권호 표지

은-알지네이트/PVP 나노섬유의 항균 특성

Antibacterial Properties of Silver-alginate/PVP Nanofiber

  • 발행 : 2013.08.10
⟨ 이전 논문 다음 논문 ⟩

초록

알지네이트에 은이온을 첨가하기 위하여, 질산은 수용액을 이용하여 은-알지네이트를 제조하였다. 본 연구에서는 은-알지네이트를 Poly vinylpyrrolidone (PVP) 수용액과 블렌드하였고, 전기방사는 블렌드 용액을 이용하여 수행하였다. 은-알지네이트/PVP 혼합 용액의 항균효과는 colony counting test로 대장균과 포도상 구균에 대해 확인하였다. 은-알지네이트/PVP 혼합용액의 전기방사 조건은 조성물의 농도를 다양하게 하여 방사거리 22 cm, 방사속도 0.01 mL/min, 전압 26 kV 조건하에서 수행하여 나노섬유를 제조하였다. 은-알지네이트 나노 섬유의 형태와 크기는 SEM과 Image J를 통해 확인하였으며, 전기방사된 SA5P15 섬유들의 평균 직경은 124 nm를 보였으며, 균일하게 방사되는 것을 확인하였다. SA5P15의 균 감소율은 24 시간 후 99.9%를 보였다.

In order to incorporate silver ions into the alginate, silver-alginate was prepared with aqueous solutions of silver nitrate. In the study, the silver-alginate was prepared by blending with poly vinylpyrrolidone solutions and the electrospinning was performed by using this blend solution. Antibacterial properties of silver-alginate/PVP solutions were estimated for Escherichia coli and Staphylococcus aureus by the colony counting test. Electrospinning conditions of silver-alginate/PVP solution were the tip-to-collector distance of 22 cm, the flow rate of the solution at 0.01 mL/min, and the voltage at 26 kV. The form and size of silver-alginate/PVP nanofibers were estimated by SEM and Image J. The average diameter of the electrospun SA5P15 fibers was 124 nm and showed a narrow diameter distribution. The reduction of bacteria for SA5P15 exhibited 99.9% after 24 h.

키워드

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