Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
권호 표지
DOI QR코드

DOI QR Code

Langerhans Cell Sarcoma in Two Young Children: Imaging Findings on Initial Presentation and Recurrence

  • Chung, Woong Do (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Im, Soo Ah (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Chung, Nak Gyun (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Park, Gyeong Sin (Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • Published : 2013.06.01
⟨ Previous Next ⟩

Abstract

Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells with malignant cytological features and multi-organ involvement that typically has a poor prognosis. We experienced 2 cases of LCS in children less than 2 years of age and report them based primarily on CT and MR findings. Both children had findings of hepatosplenomegaly with low-attenuation nodular lesions, had multiple lymphadenopathy, and had shown recurrent lesions invading the skull during follow-up after chemotherapy.

Keywords

References

  1. Zhao, G, Luo, M, Wu, ZY, Liu, Q, Zhang, B, Gao, RL,Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report, Int J Surg Pathol, 17, 1, 347-353(2009) https://doi.org/10.1177/1066896908324128
  2. Lee, JS, Ko, GH, Kim, HC, Jang, IS, Jeon, KN, Lee, JH,Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case report, J Korean Med Sci, 21, 2, 577-580(2006) https://doi.org/10.3346/jkms.2006.21.3.577
  3. Nakayama, M, Takahashi, K, Hori, M, Okumura, T, Saito, M, Yamakawa, M,Langerhans cell sarcoma of the cervical lymph node: a case report and literature review, Auris Nasus Larynx, 37, 3, 750-753(2010) https://doi.org/10.1016/j.anl.2010.04.007
  4. Luo, B, Pian, B, Peng, Z, Jintao, D, Shixi, L,Pharyngeal tonsil manifestation of Langerhans cells sarcoma: a case report and review of the literature, Int J Pediatr Otorhinolaryngol Extra, 6, 4, 156-158(2011) https://doi.org/10.1016/j.pedex.2010.06.004
  5. Uchida, K, Kobayashi, S, Inukai, T, Noriki, S, Imamura, Y, Nakajima, H,Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen, J Orthop Sci, 13, 5, 89-93(2008) https://doi.org/10.1007/s00776-007-1184-4
  6. Henter, JI, Horne, A, Aric처, M, Egeler, RM, Filipovich, AH, Imashuku, S,HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis, Pediatr Blood Cancer, 48, 6, 124-131(2007) https://doi.org/10.1002/pbc.21039
  7. Donadieu, J, Chalard, F, Jeziorski, E,Medical management of langerhans cell histiocytosis from diagnosis to treatment, Expert Opin Pharmacother, 13, 7, 1309-1322(2012) https://doi.org/10.1517/14656566.2012.688028
  8. Caruso, S, Miraglia, R, Maruzzelli, L, Luca, A, Gridelli, B,Biliary wall calcification in Langerhans cell histiocytosis: report of two cases, Pediatr Radiol, 38, 8, 791-794(2008) https://doi.org/10.1007/s00247-008-0809-x
  9. Pyun, HW, Kim, ME, Kim, JH,CT and MR findings of langerhans cell histiocytois involving the spleen: a case report, J Korean Radiol Soc, 46, 9, 171-174(2002) https://doi.org/10.3348/jkrs.2002.46.2.171
  10. Heller, GD, Haller, JO, Berdon, WE, Sane, S, Kleinman, PK,Punctate thymic calcification in infants with untreated Langerhans' cell histiocytosis: report of four new cases, Pediatr Radiol, 29, 10, 813-815(1999) https://doi.org/10.1007/s002470050702
  11. Yi, G, Yoon, HK, Kim, BK, Kim, KA, Choo, IW,CT findings of orbital langerhans cell histiocytosis, J Korean Radiol Soc, 42, 11, 841-846(2000) https://doi.org/10.3348/jkrs.2000.42.5.841

Cited by

  1. Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review vol.12, pp.5, 2013, https://doi.org/10.3892/ol.2016.5194
  2. Langerhans cell sarcoma arising from antecedent langerhans cell histiocytosis : A case report vol.98, pp.10, 2013, https://doi.org/10.1097/md.0000000000014531
  3. A Case of Langerhans Cell Sarcoma Presenting as Submandibular Gland Mass vol.62, pp.9, 2013, https://doi.org/10.3342/kjorl-hns.2018.00661
  4. Langerhans cell sarcoma involving skin and showing epidermotropism: A comprehensive review vol.48, pp.4, 2013, https://doi.org/10.1111/cup.13803