DOI QR코드

DOI QR Code

F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis

  • Lee, Hong Je (Department of Nuclear Medicine, Dongnam Institute of Radiological & Medical Sciences (DIRAMS)) ;
  • Ahn, Byeong-Cheol (Department of Nuclear Medicine, Kyungpook National University School of Medicine, Kyungpook National University Hospital) ;
  • Hwang, Seong Wook (Department of Pathology, Kyungpook National University School of Medicine, Kyungpook National University Hospital) ;
  • Cho, Suk Kyong (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Hae Won (Department of Nuclear Medicine, Kyungpook National University School of Medicine, Kyungpook National University Hospital) ;
  • Lee, Sang-Woo (Department of Nuclear Medicine, Kyungpook National University School of Medicine, Kyungpook National University Hospital) ;
  • Hwang, Jeong-Hyun (Department of Neurosurgery, Kyungpook National University School of Medicine, Kyungpook National University Hospital) ;
  • Lee, Jaetae (Department of Nuclear Medicine, Kyungpook National University School of Medicine, Kyungpook National University Hospital)
  • 발행 : 2013.04.01

초록

Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with $^{18}F$-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.

키워드

참고문헌

  1. Savitz, MH, Anderson, PJ,Primary melanoma of the leptomeninges: a review, Mt Sinai J Med, 41, 1, 774-791(1974)
  2. Smith, AB, Rushing, EJ, Smirniotopoulos, JG,Pigmented lesions of the central nervous system: radiologic-pathologic correlation, Radiographics, 29, 2, 1503-1524(2009) https://doi.org/10.1148/rg.295095109
  3. Gaetani, P, Martelli, A, Sessa, F, Zappoli, F, Rodriguez, R, Baena,Diffuse leptomeningeal melanomatosis of the spinal cord: a case report, Acta Neurochir (Wien), 121, 3, 206-211(1993) https://doi.org/10.1007/BF01809277
  4. Sagiuchi, T, Ishii, K, Utsuki, S, Asano, Y, Tsukahara, S, Kan, S,Increased uptake of technetium-99m-hexamethylpropyleneamine oxime related to primary leptomeningeal melanoma, AJNR Am J Neuroradiol, 23, 4, 1404-1406(2002)
  5. Nicolaides, P, Newton, RW, Kelsey, A,Primary malignant melanoma of meninges: atypical presentation of subacute meningitis, Pediatr Neurol, 12, 5, 172-174(1995) https://doi.org/10.1016/0887-8994(94)00155-U
  6. Bang, OY, Kim, DI, Yoon, SR, Choi, IS,Idiopathic hypertrophic pachymeningeal lesions: correlation between clinical patterns and neuroimaging characteristics, Eur Neurol, 39, 6, 49-56(1998) https://doi.org/10.1159/000007897
  7. Zadro, I, Brinar, VV, Barun, B, Ozretic, D, Pazanin, L, Grahovac, G,Primary diffuse meningeal melanomatosis, Neurologist, 16, 7, 117-119(2010) https://doi.org/10.1097/NRL.0b013e3181c29ef8
  8. Wadasadawala, T, Trivedi, S, Gupta, T, Epari, S, Jalali, R,The diagnostic dilemma of primary central nervous system melanoma, J Clin Neurosci, 17, 8, 1014-1017(2010) https://doi.org/10.1016/j.jocn.2009.12.020
  9. Pirini, MG, Mascalchi, M, Salvi, F, Tassinari, CA, Zanella, L, Bacchini, P,Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation, AJNR Am J Neuroradiol, 24, 9, 115-118(2003)
  10. Bar-Shalom, R, Yefremov, N, Guralnik, L, Gaitini, D, Frenkel, A, Kuten, A,Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management, J Nucl Med, 44, 10, 1200-1209(2003)
  11. Czernin, J, Allen-Auerbach, M, Schelbert, HR,Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006, J Nucl Med, 48, 11, 78S-88S(2007)
  12. Louis, DN, Ohgaki, H, Wiestler, OD, Cavenee, WK, Burger, PC, Jouvet, A,The 2007 WHO classification of tumours of the central nervous system, Acta Neuropathol, 114, 12, 97-109(2007) https://doi.org/10.1007/s00401-007-0243-4
  13. Hayward, RD,Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings, J Neurol Neurosurg Psychiatry, 39, 13, 526-530(1976) https://doi.org/10.1136/jnnp.39.6.526
  14. Nakhleh, RE, Wick, MR, Rocamora, A, Swanson, PE, Dehner, LP,Morphologic diversity in malignant melanomas, Am J Clin Pathol, 93, 14, 731-740(1990) https://doi.org/10.1093/ajcp/93.6.731
  15. Ohsie, SJ, Sarantopoulos, GP, Cochran, AJ, Binder, SW,Immunohistochemical characteristics of melanoma, J Cutan Pathol, 35, 15, 433-444(2008) https://doi.org/10.1111/j.1600-0560.2007.00891.x
  16. Brat, DJ, Giannini, C, Scheithauer, BW, Burger, PC,Primary melanocytic neoplasms of the central nervous systems, Am J Surg Pathol, 23, 16, 745-754(1999) https://doi.org/10.1097/00000478-199907000-00001
  17. Liubinas, SV, Maartens, N, Drummond, KJ,Primary melanocytic neoplasms of the central nervous system, J Clin Neurosci, 17, 17, 1227-1232(2010) https://doi.org/10.1016/j.jocn.2010.01.017
  18. Lee, NK, Lee, BH, Hwang, YJ, Sohn, MJ, Chang, S, Kim, YH,Findings from CT, MRI, and PET/CT of a primary malignant melanoma arising in a spinal nerve root, Eur Spine J, 19, 18, S174-S178(2010) https://doi.org/10.1007/s00586-010-1285-1
  19. Bastiaannet, E, Oyen, WJ, Meijer, S, Hoekstra, OS, Wobbes, T, Jager, PL,Impact of [18F]fluorodeoxyglucose positron emission tomography on surgical management of melanoma patients, Br J Surg, 93, 19, 243-249(2006) https://doi.org/10.1002/bjs.5174

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